Guanine

Guanine

SCHEMBL101892

Nc1nc2[nH]cnc2c(=O)[nH]1.O=P(O)(O)OP(=O)(O)O

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.48
ALDH1A1 P00352 1/20 0.48
LMNA P02545 1/20 0.48
GLA P06280 1/20 0.48
PMP22 Q01453 1/20 0.48
HSD17B10 Q99714 1/20 0.48
PNP P00491 5/20 0.44
POLB P06746 2/20 0.44
POLG P54098 2/20 0.43
POLA1 P09884 1/20 0.42
HPRT1 P00492 8/20 0.39
DYRK1A Q13627 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Triphosphate SCHEMBL28101758 0.94 PNP (0.50) KDM4EALDH1A1LMNAGLAPMP22
Guanine SCHEMBL663745 0.91 KDM4E (0.53) KDM4EALDH1A1LMNAGLAPMP22
Guanine SCHEMBL76053 0.91 KDM4E (0.53) KDM4EALDH1A1LMNAGLAPMP22
Guanine SCHEMBL5372452 0.90 KDM4E (0.51) KDM4EALDH1A1LMNAGLAPMP22
Guanine SCHEMBL15948930 0.88 KDM4E (0.50) KDM4EALDH1A1LMNAGLAPMP22
Guanine SCHEMBL4658042 0.86 ALDH1A1 (0.61) KDM4EALDH1A1LMNAGLAPMP22
Guanine SCHEMBL5259 0.86 ALDH1A1 (0.61) KDM4EALDH1A1LMNAGLAPMP22
Guanine SCHEMBL27542045 0.85 HSD17B10 (0.56) KDM4EALDH1A1LMNAGLAPMP22
Guanine SCHEMBL2895087 0.85 ALDH1A1 (0.59) KDM4EALDH1A1LMNAGLAPMP22
Guanine SCHEMBL21611717 0.85 ALDH1A1 (0.59) KDM4EALDH1A1LMNAGLAPMP22

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 330 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4087611-A1 SHP2 INHIBITOR DOSING AND METHODS OF TREATING CANCER Revolution Medicines, Inc. (US) 2022-11-16 EP claimed
CN-114929279-A Methods of administering SHP2 inhibitors and treating cancer 锐新医药公司 2022-08-19 CN claimed
US-20220110871-A1 PHARMACEUTICAL PREPARATION OF CARBOHYDRATES FOR THERAPEUTIC USE GLYCOMINE, INC. (US) 2022-04-14 US claimed
EP-3954360-A2 PHARMACEUTICAL PREPARATION OF CARBOHYDRATES FOR THERAPEUTIC USE Glycomine, Inc. (US) 2022-02-16 EP claimed
US-20200246266-A1 PHARMACEUTICAL PREPARATION OF CARBOHYDRATES FOR THERAPEUTIC USE GLYCOMINE, INC. (US) 2020-08-06 US claimed
WO-2019034597-A1 FORCE-RESPONSIVE POLYMERSOMES AND NANOREACTORS; PROCESSES UTILIZING THE SAME ADOLPHE MERKLE INSTITUTE, UNIVERSITY OF FRIBOURG (CH) 2019-02-21 WO claimed
US-20180036239-A1 PHARMACEUTICAL PREPARATION OF CARBOHYDRATES FOR THERAPEUTIC USE GLYCOMINE, INC. (US) 2018-02-08 US claimed
US-20160228364-A1 PHARMACEUTICAL PREPARATION OF CARBOHYDRATES FOR THERAPEUTIC USE GLYCOMINE, INC. (US) 2016-08-11 US claimed
EP-3046537-A2 PHARMACEUTICAL PREPARATION OF CARBOHYDRATES FOR THERAPEUTIC USE Glycomine, Inc. (US) 2016-07-27 EP claimed
WO-2015053910-A2 PHARMACEUTICAL PREPARATION OF CARBOHYDRATES FOR THERAPEUTIC USE GLYCOMINE LLC (US) 2015-04-16 WO claimed
US-20140329699-A1 SYSTEMS AND METHODS FOR HIGH EFFICIENCY ELECTRONIC SEQUENCING AND DETECTION OXFORD FINANCE LLC, AS COLLATERAL AGENT 2014-11-06 US claimed
EP-2785868-A1 SYSTEMS AND METHODS FOR HIGH EFFICIENCY ELECTRONIC SEQUENCING AND DETECTION Genapsys Inc. (US) 2014-10-08 EP claimed
WO-2013082619-A1 SYSTEMS AND METHODS FOR HIGH EFFICIENCY ELECTRONIC SEQUENCING AND DETECTION GENAPSYS, INC. (US) 2013-06-06 WO claimed
US-8383597-B2 G proteins in tumor growth and angiogenesis CORNELL RESEARCH FOUNDATION, INC. (US) 2013-02-26 US claimed
US-8173620-B2 BHQ-caged nucleotide probes photolysable by two-photon excitation UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 2012-05-08 US claimed
US-20100048502-A1 BHQ-CAGED NUCLEOTIDE PROBES PHOTOLYSABLE BY TWO-PHOTON EXCITATION NATIONAL SCIENCE FOUNDATION 2010-02-25 US claimed
CN-101495504-A Materials and methods for the generation of fully 2'-modified nucleic acid transcripts ARCHEMIX CORP (US) 2009-07-29 CN claimed
US-20080020994-A1 G proteins in tumor growth and angiogenesis CORNELL RESEARCH FOUNDATION, INC. (US) 2008-01-24 US claimed
US-20260094669-A1 EPITOPE PREDICTION VIA A LEARNED GENOTYPE NETWORK ACROSS CLASS II MHC ALLELES SEATTLE PROJECT CORP (US) 2026-04-02 US disclosed
WO-1994029727-A1 INHIBITING PROTEIN INTERACTIONS THE GENERAL HOSPITAL CORPORATION (US) 1994-12-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260094669-A1 EPITOPE PREDICTION VIA A LEARNED GENOTYPE NETWORK ACROSS CLASS II MHC ALLELES MICA, HLA-DRB1, TAP2 KDM4E 2641/4885ALDH1A1 4709/4885LMNA 948/4885
US-20100048502-A1 BHQ-CAGED NUCLEOTIDE PROBES PHOTOLYSABLE BY TWO-PHOTON EXCITATION NUDT1, RECQL, PNP KDM4E 971/4885ALDH1A1 1338/4885LMNA 1447/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.