SCHEMBL10192089

SCHEMBL10192089

Cc1ccc(NS(=O)(=O)c2cn(C)cn2)cc1

nearest known ligand 0.70

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.70
L3MBTL1 Q9Y468 1/20 0.70
ALDH1A1 P00352 3/20 0.65
MAPK1 P28482 1/20 0.65
SMN1; SMN2 Q16637 1/20 0.65
HTR6 P50406 1/20 0.52
ITK Q08881 1/20 0.52
GLO1 Q04760 1/20 0.51
LMNA P02545 1/20 0.50
SLC6A9 P48067 1/20 0.48
GAA P10253 3/20 0.48
KMT2A Q03164 1/20 0.48
FBP1 P09467 1/20 0.46
MET P08581 1/20 0.45
SYK P43405 1/20 0.44
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43
KDM4E B2RXH2 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18862468 0.86 TSHR (0.68) TSHRL3MBTL1ALDH1A1MAPK1SMN1; SMN2
SCHEMBL25848742 0.84 TSHR (0.65) TSHRL3MBTL1ALDH1A1MAPK1SMN1; SMN2
SCHEMBL28752749 0.83 TSHR (0.64) TSHRL3MBTL1ALDH1A1MAPK1SMN1; SMN2
SCHEMBL23113013 0.77 TSHR (0.57) TSHRL3MBTL1ALDH1A1MAPK1SMN1; SMN2
SCHEMBL14721723 0.75 TSHR (0.51) TSHRL3MBTL1ALDH1A1MAPK1SMN1; SMN2
SCHEMBL4070446 0.74 LMNA (0.55) TSHRL3MBTL1ALDH1A1MAPK1SMN1; SMN2
SCHEMBL1037880 0.73 SLC40A1 (0.54) ALDH1A1MAPK1LMNAGAAKMT2A
SCHEMBL289059 0.73 LMNA (0.54) TSHRL3MBTL1ALDH1A1MAPK1SMN1; SMN2
SCHEMBL420412 0.73 LMNA (0.54) TSHRL3MBTL1ALDH1A1MAPK1SMN1; SMN2
SCHEMBL6427335 0.72 LMNA (0.54) TSHRL3MBTL1ALDH1A1MAPK1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3793990-B1 ANTIBACTERIAL COMPOUNDS INFEX THERAPEUTICS LTD (GB) 2023-07-19 EP disclosed
US-20230060011-A1 ANTIBACTERIAL COMPOUNDS Infex Therapeutics Limited (GB) 2023-02-23 US disclosed
US-20190382422-A1 SALICYLIC ACID DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, COMPOSITION THEREOF AND METHOD OF USE THEREOF THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) 2019-12-19 US disclosed
US-10377780-B2 Salicylic acid derivatives, pharmaceutically acceptable salt thereof, composition thereof and method of use thereof THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) 2019-08-13 US disclosed
US-20170267704-A1 SALICYLIC ACID DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, COMPOSITION THEREOF AND METHOD OF USE THEREOF THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) 2017-09-21 US disclosed
US-20170267704-A1 SALICYLIC ACID DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, COMPOSITION THEREOF AND METHOD OF USE THEREOF THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) 2017-09-21 US disclosed
US-9650399-B2 Salicylic acid derivatives, pharmaceutically acceptable salt thereof, composition thereof and method of use thereof THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) 2017-05-16 US disclosed
US-9650399-B2 Salicylic acid derivatives, pharmaceutically acceptable salt thereof, composition thereof and method of use thereof THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) 2017-05-16 US disclosed
US-20150158894-A1 SALICYCLIC ACID DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, COMPOSITION THEREOF AND METHOD OF USE THEREOF UTI LIMITED PARTNERSHIP (CA) 2015-06-11 US disclosed
US-20150158894-A1 SALICYCLIC ACID DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, COMPOSITION THEREOF AND METHOD OF USE THEREOF UTI LIMITED PARTNERSHIP (CA) 2015-06-11 US disclosed
US-20120009142-A1 METHODS FOR TREATING HEPATITIS C PTC THERAPEUTICS, INC. (US) 2012-01-12 US disclosed
US-7973069-B2 Methods for treating hepatitis C PTC THERAPEUTICS, INC. (US) 2011-07-05 US disclosed
US-20100305100-A1 METHODS FOR TREATING HEPATITIS C PTC THERAPEUTICS, INC. (US) 2010-12-02 US disclosed
US-20100292187-A1 METHODS FOR TREATING HEPATITIS C PTC THERAPEUTICS, INC. (US) 2010-11-18 US disclosed
WO-2007084435-A2 METHODS FOR TREATING HEPATITIS C PTC THERAPEUTICS, INC. (US) 2007-07-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190382422-A1 SALICYLIC ACID DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, COMPOSITION THEREOF AND METHOD OF USE THEREOF STAT3, STAT5A, STAT6 TSHR 3326/4885L3MBTL1 3622/4885ALDH1A1 722/4885
US-20230060011-A1 ANTIBACTERIAL COMPOUNDS GAA, MGAM, NQO1 TSHR 4699/4885L3MBTL1 3332/4885ALDH1A1 291/4885
US-20120009142-A1 METHODS FOR TREATING HEPATITIS C OAT, HAVCR2, HCCS TSHR 4324/4885L3MBTL1 2809/4885ALDH1A1 591/4885
US-20170267704-A1 SALICYLIC ACID DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, COMPOSITION THEREOF AND METHOD OF USE THEREOF STAT3, STAT5A, STAT6 TSHR 3326/4885L3MBTL1 3622/4885ALDH1A1 722/4885
US-20100292187-A1 METHODS FOR TREATING HEPATITIS C HAVCR2, EIF2AK2, MAVS TSHR 4161/4885L3MBTL1 3501/4885ALDH1A1 1497/4885
US-10377780-B2 Salicylic acid derivatives, pharmaceutically acceptable salt thereof, composition thereof and method of use thereof STAT3, STAT5A, STAT6 TSHR 3326/4885L3MBTL1 3622/4885ALDH1A1 722/4885
US-20100305100-A1 METHODS FOR TREATING HEPATITIS C HAVCR2, EIF2AK2, MAVS TSHR 4161/4885L3MBTL1 3501/4885ALDH1A1 1497/4885
US-20150158894-A1 SALICYCLIC ACID DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, COMPOSITION THEREOF AND METHOD OF USE THEREOF STAT3, STAT5A, JAK2 TSHR 3129/4885L3MBTL1 3909/4885ALDH1A1 836/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.