Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | ACLY | P53396 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6267077 | 0.98 | THRB (0.46) | THRBIDO1HSD17B10ALDH1A1TSHR | |
| SCHEMBL374815 | 0.82 | HSD17B10 (0.58) | THRBIDO1HSD17B10ALDH1A1TSHR | |
| SCHEMBL4929798 | 0.75 | GAA (0.41) | ALDH1A1TSHRCYP3A4CA1CA2 | |
| SCHEMBL5399616 | 0.75 | ERN1 (0.46) | THRBIDO1HSD17B10ALDH1A1TSHR | |
| SCHEMBL29674856 | 0.75 | ALDH1A1 (0.43) | ALDH1A1TSHRCYP3A4CA1CA2 | |
| SCHEMBL9387233 | 0.75 | ALDH1A1 (0.43) | ALDH1A1TSHRCYP3A4CA1CA2 | |
| SCHEMBL4704877 | 0.75 | ALDH1A1 (0.43) | ALDH1A1TSHRCYP3A4CA1CA2 | |
| SCHEMBL2253709 | 0.75 | TSHR (0.65) | THRBHSD17B10ALDH1A1TSHRTTR | |
| SCHEMBL104581 | 0.75 | ERN1 (0.46) | IDO1ALDH1A1CA1CA12CA9 | |
| SCHEMBL2806380 | 0.75 | TTR (0.65) | THRBHSD17B10ALDH1A1TSHRTTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4619388-A1 | CATHEPSIN L INHIBITORS | Biofront Therapeutics (Beijing) Co., Ltd. (CN) | 2025-09-24 | — | — | EP | disclosed |
| WO-2024140356-A1 | CATHEPSIN L INHIBITORS | BIOFRONT THERAPEUTICS (BEIJING) CO., LTD. (CN) | 2024-07-04 | — | — | WO | disclosed |
| US-11858905-B1 | Cathepsin L inhibitors | BIOFRONT THERAPEUTICS (BEIJING) CO., LTD. (CN) | 2024-01-02 | — | — | US | disclosed |
| CN-116589425-A | Cathepsin L inhibitors | 百放英库医药科技(北京)有限公司 | 2023-08-15 | — | — | CN | disclosed |
| US-8883826-B2 | Alkynyl derivatives as modulators of metabotropic glutamate receptors | ADDEX PHARMA SA (CH) | 2014-11-11 | — | — | US | disclosed |
| US-8674106-B2 | Alkynyl derivatives as modulators of metabotropic glutamate receptors | ADDEX PHARMA SA (CH) | 2014-03-18 | — | — | US | disclosed |
| US-20130178631-A1 | NOVEL ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA SA (CH) | 2013-07-11 | — | — | US | disclosed |
| CN-102993084-A | Alkynyl derivatives as modulators of metabotropic glutamate receptors | ADDEX PHARMACEUTICALS SA | 2013-03-27 | — | — | CN | disclosed |
| CN-101001846-B | Alkynyl derivatives as modulators of metabotropic glutamate receptors | ADDEX PHARMACEUTICALS SA | 2012-11-07 | — | — | CN | disclosed |
| US-20120277237-A1 | NOVEL ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA SA (CH) | 2012-11-01 | — | — | US | disclosed |
| CN-101001846-A | Novel alkynyl derivatives as modulators of metabotropic glutamate receptors | ADDEX PHARMACEUTICALS SA (CH) | 2007-07-18 | — | — | CN | disclosed |
| EP-1765795-A2 | ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharmaceuticals SA (CH) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005123703-A2 | ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMACEUTICALS SA (CH) | 2005-12-29 | — | — | WO | disclosed |
| CN-1195753-C | Fused benzene derivatives useful as herbicides | ISHIHARA SANGYO KAISHA (JP) | 2005-04-06 | — | — | CN | disclosed |
| US-20040029734-A1 | Fused-benzene derivatives useful as herbicides | ISHIHARA SANGYO KAISHA, LTD. | 2004-02-12 | — | — | US | disclosed |
| US-6573218-B1 | Defoliants containing such as uracil and 1,4-benzoxazole or benzthiazole moieties | ISHIHARA SANGYO KAISHA, LTD. (JP) | 2003-06-03 | — | — | US | disclosed |
| EP-1111993-A4 | FUSED-BENZENE DERIVATIVES USEFUL AS HERBICIDES | ISHIHARA SANGYO KAISHA (JP) | 2002-12-04 | — | — | EP | disclosed |
| CN-1325267-A | Fused-benzene derivatives useful as herbicides | ISHIHARA SANGYO KAISHA (JP) | 2001-12-05 | — | — | CN | disclosed |
| EP-1111993-A1 | FUSED-BENZENE DERIVATIVES USEFUL AS HERBICIDES | ISHIHARA SANGYO KAISHA, LTD. (JP) | 2001-07-04 | — | — | EP | disclosed |
| WO-2000013508-A1 | FUSED-BENZENE DERIVATIVES USEFUL AS HERBICIDES | ISHIHARA SANGYO KAISHA, LTD. (JP) | 2000-03-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130178631-A1 | NOVEL ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | GRM5, GRM1, GRM2 | THRB 653/4885IDO1 3816/4885HSD17B10 1829/4885 |
| US-20040029734-A1 | Fused-benzene derivatives useful as herbicides | DDT, NQO2, DHRS9 | THRB 2092/4885IDO1 2382/4885HSD17B10 1963/4885 |
| US-11858905-B1 | Cathepsin L inhibitors | CTSV, CTSL, CTSB | THRB 4286/4885IDO1 2904/4885HSD17B10 3178/4885 |
| US-20120277237-A1 | NOVEL ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | GRM5, GRM1, GRM2 | THRB 653/4885IDO1 3816/4885HSD17B10 1829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.