Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.51 |
| ▸ | CES1 | P23141 | 2/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 7/20 | 0.47 |
| ▸ | NOS2 | P35228 | 2/20 | 0.46 |
| ▸ | ATP1A1 | P05023 | 2/20 | 0.45 |
| ▸ | ATP1B1 | P05026 | 2/20 | 0.45 |
| ▸ | ATP1A3 | P13637 | 2/20 | 0.45 |
| ▸ | ATP1B2 | P14415 | 2/20 | 0.45 |
| ▸ | ATP1A2 | P50993 | 2/20 | 0.45 |
| ▸ | ATP1B3 | P54709 | 2/20 | 0.45 |
| ▸ | FXYD2 | P54710 | 2/20 | 0.45 |
| ▸ | ATP1A4 | Q13733 | 2/20 | 0.45 |
| ▸ | F3 | P13726 | 1/20 | 0.42 |
| ▸ | PNLIP | P16233 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NT5E | P21589 | 1/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.40 |
| ▸ | ACP1 | P24666 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12698978 | 1.00 | CES2 (0.51) | CES2CES1PTPN1NOS2ATP1A1 | |
| SCHEMBL10227229 | 0.89 | ATP1A1 (0.46) | CES2CES1PTPN1NOS2ATP1A1 | |
| SCHEMBL12828389 | 0.87 | NOS2 (0.43) | CES2CES1PTPN1NOS2ATP1A1 | |
| SCHEMBL12200193 | 0.87 | NOS2 (0.43) | CES2CES1PTPN1NOS2ATP1A1 | |
| SCHEMBL10226986 | 0.87 | NOS2 (0.43) | CES2CES1PTPN1NOS2ATP1A1 | |
| SCHEMBL12200194 | 0.87 | NOS2 (0.43) | CES2CES1PTPN1NOS2ATP1A1 | |
| SCHEMBL12200254 | 0.86 | NOS2 (0.43) | CES2CES1PTPN1NOS2ATP1A1 | |
| SCHEMBL21814540 | 0.86 | CES2 (0.54) | CES2CES1PTPN1NOS2ATP1A1 | |
| SCHEMBL14942406 | 0.86 | NOS2 (0.64) | CES2CES1PTPN1NOS2ATP1A1 | |
| SCHEMBL16380377 | 0.86 | NOS2 (0.54) | CES2CES1PTPN1NOS2ATP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124656-B2 | Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring | REATA PHARMACEUTICALS, INC. (US) | 2012-02-28 | — | — | US | disclosed |
| US-20110245233-A1 | ANTIOXIDANT INFLAMMATION MODULATORS: OLEANOLIC ACID DERIVATIVES WITH SATURATION IN THE C-RING | REATA PHARMACEUTICALS, INC. | 2011-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245233-A1 | ANTIOXIDANT INFLAMMATION MODULATORS: OLEANOLIC ACID DERIVATIVES WITH SATURATION IN THE C-RING | HMOX1, ALOX12, ALOX15 | CES2 3304/4885CES1 541/4885PTPN1 4282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.