SCHEMBL1022686

SCHEMBL1022686

COC(=O)Nc1ccc(Cc2ccc(NC(=O)OC)cc2)cc1

nearest known ligand 0.66

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 0.64
SAE1 Q9UBE0 3/20 0.62
UBA2 Q9UBT2 3/20 0.62
MAPT P10636 2/20 0.59
RAB9A P51151 3/20 0.56
NPC1 O15118 1/20 0.56
HPGD P15428 1/20 0.55
TSHR P16473 1/20 0.53
CYP17A1 P05093 1/20 0.53
LMNA P02545 4/20 0.52
KMT2A Q03164 3/20 0.52
POLB P06746 3/20 0.52
MEN1 O00255 2/20 0.52
ALDH1A1 P00352 2/20 0.47
KDM4E B2RXH2 1/20 0.47
GAA P10253 1/20 0.47
GFER P55789 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17129481 0.94 SMN1; SMN2 (0.58) SMN1; SMN2SAE1UBA2MAPTRAB9A
SCHEMBL2097449 0.93 SMN1; SMN2 (0.67) SMN1; SMN2SAE1UBA2MAPTRAB9A
SCHEMBL18183585 0.93 SMN1; SMN2 (0.56) SMN1; SMN2SAE1UBA2MAPTRAB9A
SCHEMBL13647687 0.93 SMN1; SMN2 (0.56) SMN1; SMN2SAE1UBA2MAPTRAB9A
SCHEMBL14802652 0.93 SMN1; SMN2 (0.79) SMN1; SMN2SAE1UBA2MAPTRAB9A
SCHEMBL11134616 0.91 SMN1; SMN2 (0.55) SMN1; SMN2SAE1UBA2MAPTRAB9A
SCHEMBL21456399 0.89 SMN1; SMN2 (0.53) SMN1; SMN2SAE1UBA2MAPTRAB9A
SCHEMBL18548480 0.88 L3MBTL1 (0.61) SMN1; SMN2SAE1UBA2MAPTRAB9A
SCHEMBL9609808 0.87 SMN1; SMN2 (0.82) SMN1; SMN2MAPTRAB9ANPC1HPGD
SCHEMBL22001268 0.87 SMN1; SMN2 (0.50) SMN1; SMN2SAE1UBA2MAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4069240-A GROUP 8 METAL CATALYST UNIROYAL, INC. (US) 1978-01-17 US claimed
US-20230275259-A1 INORGANIC SOLID ELECTROLYTE-CONTAINING COMPOSITION, SHEET FOR ALL-SOLID STATE SECONDARY BATTERY, AND ALL-SOLID STATE SECONDARY BATTERY, AND MANUFACTURING METHODS FOR SHEET FOR ALL-SOLID STATE SECONDARY BATTERY AND ALL-SOLID STATE SECONDARY BATTERY FUJIFILM CORPORATION (JP) 2023-08-31 US disclosed
US-11565997-B2 Method for preparing dicarbamate compounds from diamines and the catalyst thereof KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2023-01-31 US disclosed
EP-3630717-B1 A PROCESS FOR THE SYNTHESIS OF AROMATIC CARBAMATES COUNCIL SCIENT IND RES (IN) 2022-02-09 EP disclosed
US-20220002236-A1 The method for preparing dicarbamate compounds from diamines and the catalyst thereof KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2022-01-06 US disclosed
EP-3625210-B1 SILICA-BASED ZINC CATALYSTS. THEIR PREPARATION AND USE IN THE ALKOXYCARBONYLATION OF AMINES COVESTRO INTELLECTUAL PROPERTY GMBH & CO KG (DE) 2021-06-23 EP disclosed
US-10807084-B2 Silica-based zinc catalysts, their preparation and use in the alkoxycarbonylation of amines COVESTRO DEUTSCHLAND AG (DE) 2020-10-20 US disclosed
US-10703714-B2 Process for the synthesis of aromatic carbamates COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2020-07-07 US disclosed
US-20200147594-A1 SILICA-BASED ZINC CATALYSTS, THEIR PREPARATION AND USE IN THE ALKOXYCARBONYLATION OF AMINES COVESTRO DEUTSCHLAND AG (DE) 2020-05-14 US disclosed
US-20200148631-A1 A PROCESS FOR THE SYNTHESIS OF AROMATIC CARBAMATES COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2020-05-14 US disclosed
EP-0018581-B1 PROCESS FOR THE PREPARATION OF ARYL-MONO- AND/OR POLYURETHANES BASF Aktiengesellschaft (DE) 1983-05-25 EP disclosed
US-4375000-A Process for the preparation of an aryl mono-, di-, and/or polyurethane BASF AKTIENGESELLSCHAFT (DE) 1983-02-22 US disclosed
US-4319018-A IN ACID CATALYST MITSUI TOATSU CHEMICALS, INC. (JP) 1982-03-09 US disclosed
EP-0036895-A1 Process for preparing aromatic urethanes BASF Aktiengesellschaft (DE) 1981-10-07 EP disclosed
EP-0018581-A1 Process for the preparation of aryl-mono- and/or polyurethanes BASF Aktiengesellschaft (DE) 1980-11-12 EP disclosed
US-4096291-A HYDROXYL COMPOUNDS AND BLOCKED POLYISOCYANATES; CROSSLINKING BAYER AKTIENGESELLSCHAFT (DT) 1978-06-20 US disclosed
US-4069240-A GROUP 8 METAL CATALYST UNIROYAL, INC. (US) 1978-01-17 US disclosed
US-4069240-A GROUP 8 METAL CATALYST UNIROYAL, INC. (US) 1978-01-17 US disclosed
US-4005056-A Process for the preparation of polyhydantoins and polyparanic acids BAYER AKTIENGESELLSCHAFT (DT) 1977-01-25 US disclosed
US-3961009-A EXTRUSION, FILMS, SOLVENT EXTRACTION, CURING TORAY INDUSTRIES, INC. (JA) 1976-06-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200147594-A1 SILICA-BASED ZINC CATALYSTS, THEIR PREPARATION AND USE IN THE ALKOXYCARBONYLATION OF AMINES CDYL, ZYX, CXXC4 SMN1; SMN2 4655/4885SAE1 736/4885UBA2 2065/4885
US-11565997-B2 Method for preparing dicarbamate compounds from diamines and the catalyst thereof AOC1, PPOX, SMOX SMN1; SMN2 2242/4885SAE1 2960/4885UBA2 3359/4885
US-20200148631-A1 A PROCESS FOR THE SYNTHESIS OF AROMATIC CARBAMATES TYR, DDC, ALK SMN1; SMN2 4574/4885SAE1 2184/4885UBA2 915/4885
US-10703714-B2 Process for the synthesis of aromatic carbamates ALK, DDC, TYR SMN1; SMN2 4611/4885SAE1 1965/4885UBA2 1057/4885
US-10807084-B2 Silica-based zinc catalysts, their preparation and use in the alkoxycarbonylation of amines CDYL, ZYX, CXXC4 SMN1; SMN2 4655/4885SAE1 736/4885UBA2 2065/4885
US-20220002236-A1 The method for preparing dicarbamate compounds from diamines and the catalyst thereof AOC1, DDO, PPOX SMN1; SMN2 2307/4885SAE1 2843/4885UBA2 3063/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.