Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 4/20 | 0.61 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.57 |
| ▸ | CLK1 | P49759 | 1/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13814194 | 0.90 | FLT3 (0.68) | FLT3MAP2K1CLK1DYRK1ANPC1 | |
| SCHEMBL10227650 | 0.88 | FLT3 (0.65) | FLT3MAP2K1CLK1DYRK1ANPC1 | |
| SCHEMBL426115 | 0.88 | NPC1 (0.62) | FLT3NPC1RAB9AEGFRPIK3CA | |
| SCHEMBL10227643 | 0.84 | FLT3 (0.59) | FLT3MAP2K1CLK1DYRK1ANPC1 | |
| SCHEMBL13814181 | 0.84 | CASP3 (0.54) | FLT3CLK1DYRK1ANPC1RAB9A | |
| SCHEMBL22887391 | 0.84 | CASP3 (0.68) | NPC1RAB9AKDM4EMAPTDAO | |
| SCHEMBL10226225 | 0.83 | NPC1 (0.54) | FLT3MAP2K1NPC1RAB9AEGFR | |
| SCHEMBL13814197 | 0.83 | NPC1 (0.54) | FLT3MAP2K1NPC1RAB9AEGFR | |
| SCHEMBL2729915 | 0.81 | FLT3 (0.79) | FLT3MAP2K1CLK1DYRK1ANPC1 | |
| SCHEMBL10226047 | 0.81 | GPR84 (0.55) | NPC1RAB9AMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022121-A1 | INDOLES, DERIVATIVES AND ANALOGS THEREOF AND USES THEREFOR | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2012-01-26 | — | — | US | disclosed |
| US-20120022121-A1 | INDOLES, DERIVATIVES AND ANALOGS THEREOF AND USES THEREFOR | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2012-01-26 | — | — | US | disclosed |
| US-20120022121-A1 | INDOLES, DERIVATIVES AND ANALOGS THEREOF AND USES THEREFOR | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2012-01-26 | — | — | US | disclosed |
| CN-101932569-A | Indoles, its derivative and analogue and uses thereof | UNIV OHIO STATE RES FOUND | 2010-12-29 | — | — | CN | disclosed |
| EP-2222659-A1 | INDOLES, DERIVATIVES, AND ANALOGS THEREOF AND USES THEREOF | The Ohio State University Research Foundation (US) | 2010-09-01 | — | — | EP | disclosed |
| US-20090142832-A1 | Indoles, Derivatives, and Analogs Thereof and Uses Therefor | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2009-06-04 | — | — | US | disclosed |
| US-20090142832-A1 | Indoles, Derivatives, and Analogs Thereof and Uses Therefor | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2009-06-04 | — | — | US | disclosed |
| US-20090142832-A1 | Indoles, Derivatives, and Analogs Thereof and Uses Therefor | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2009-06-04 | — | — | US | disclosed |
| WO-2009070645-A1 | INDOLES, DERIVATIVES, AND ANALOGS THEREOF AND USES THEREOF | THE OHIO UNIVERSITY RESEARCH FOUNDATION (US) | 2009-06-04 | — | — | WO | disclosed |
| WO-2009070645-A1 | INDOLES, DERIVATIVES, AND ANALOGS THEREOF AND USES THEREOF | THE OHIO UNIVERSITY RESEARCH FOUNDATION (US) | 2009-06-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022121-A1 | INDOLES, DERIVATIVES AND ANALOGS THEREOF AND USES THEREFOR | TUBB, TUBB3, TUBB1 | FLT3 3889/4885MAP2K1 1533/4885CLK1 2230/4885 |
| US-20090142832-A1 | Indoles, Derivatives, and Analogs Thereof and Uses Therefor | TUBB, TUBB1, TUBB6 | FLT3 3133/4885MAP2K1 2469/4885CLK1 2821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.