Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 3/20 | 0.59 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.59 |
| ▸ | FLT3 | P36888 | 4/20 | 0.58 |
| ▸ | SMO | Q99835 | 2/20 | 0.53 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.50 |
| ▸ | TUBB | P07437 | 3/20 | 0.50 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.50 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.50 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.50 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.50 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.50 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.50 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.50 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.50 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.50 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.50 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.50 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.50 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL426783 | 0.86 | PDGFRB (0.74) | PDGFRBPDGFRAFLT3SMOTUBB4A | |
| SCHEMBL10227650 | 0.82 | FLT3 (0.65) | PDGFRBPDGFRAFLT3MEN1KMT2A | |
| SCHEMBL424789 | 0.81 | SMO (0.63) | PDGFRBPDGFRASMOTUBB4ATUBB | |
| SCHEMBL10176444 | 0.81 | FLT3 (0.55) | PDGFRBPDGFRAFLT3MEN1KMT2A | |
| SCHEMBL10227643 | 0.79 | FLT3 (0.59) | PDGFRBPDGFRAFLT3MEN1KMT2A | |
| SCHEMBL6395697 | 0.79 | MEN1 (0.73) | PDGFRBPDGFRAFLT3MEN1KMT2A | |
| SCHEMBL430038 | 0.78 | TUBB4A (0.59) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL423127 | 0.77 | FLT3 (0.61) | PDGFRBPDGFRAFLT3MEN1KMT2A | |
| SCHEMBL29260977 | 0.75 | TUBB4A (0.56) | PDGFRBPDGFRASMOTUBB4ATUBB | |
| SCHEMBL10227642 | 0.75 | FLT3 (0.54) | PDGFRBPDGFRAFLT3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022121-A1 | INDOLES, DERIVATIVES AND ANALOGS THEREOF AND USES THEREFOR | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2012-01-26 | — | — | US | disclosed |
| US-20120022121-A1 | INDOLES, DERIVATIVES AND ANALOGS THEREOF AND USES THEREFOR | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2012-01-26 | — | — | US | disclosed |
| US-20120022121-A1 | INDOLES, DERIVATIVES AND ANALOGS THEREOF AND USES THEREFOR | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2012-01-26 | — | — | US | disclosed |
| EP-2222659-A1 | INDOLES, DERIVATIVES, AND ANALOGS THEREOF AND USES THEREOF | The Ohio State University Research Foundation (US) | 2010-09-01 | — | — | EP | disclosed |
| US-20090142832-A1 | Indoles, Derivatives, and Analogs Thereof and Uses Therefor | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2009-06-04 | — | — | US | disclosed |
| US-20090142832-A1 | Indoles, Derivatives, and Analogs Thereof and Uses Therefor | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2009-06-04 | — | — | US | disclosed |
| US-20090142832-A1 | Indoles, Derivatives, and Analogs Thereof and Uses Therefor | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2009-06-04 | — | — | US | disclosed |
| WO-2009070645-A1 | INDOLES, DERIVATIVES, AND ANALOGS THEREOF AND USES THEREOF | THE OHIO UNIVERSITY RESEARCH FOUNDATION (US) | 2009-06-04 | — | — | WO | disclosed |
| WO-2009070645-A1 | INDOLES, DERIVATIVES, AND ANALOGS THEREOF AND USES THEREOF | THE OHIO UNIVERSITY RESEARCH FOUNDATION (US) | 2009-06-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022121-A1 | INDOLES, DERIVATIVES AND ANALOGS THEREOF AND USES THEREFOR | TUBB, TUBB3, TUBB1 | PDGFRB 2578/4885PDGFRA 2983/4885FLT3 3889/4885 |
| US-20090142832-A1 | Indoles, Derivatives, and Analogs Thereof and Uses Therefor | TUBB, TUBB1, TUBB6 | PDGFRB 2227/4885PDGFRA 2659/4885FLT3 3133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.