Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 2/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5836519 | 0.87 | MAPT (0.53) | ADORA3MAPTSMN1; SMN2HPGDRAB9A | |
| SCHEMBL17303477 | 0.85 | RXFP1 (0.44) | MAPTHPGDRAB9ALMNAKMT2A | |
| SCHEMBL1111577 | 0.83 | KDM4E (0.47) | SMN1; SMN2RAB9ATP53GAA | |
| SCHEMBL182044 | 0.82 | ALDH1A1 (0.55) | MAPTSMN1; SMN2HPGDRAB9ALMNA | |
| SCHEMBL28005157 | 0.81 | METAP2 (0.32) | XDHADORA3LMNAKMT2A | |
| SCHEMBL3086806 | 0.81 | MAPK1 (0.48) | KMT2A | |
| SCHEMBL4789775 | 0.81 | ALDH1A1 (0.36) | XDHADORA3MAPTRAB9ALMNA | |
| Acetophenone SCHEMBL28143975 | 0.81 | MAPT (0.41) | XDHADORA3MAPTSMN1; SMN2HPGD | |
| SCHEMBL12647574 | 0.81 | MAP4K4 (0.50) | BRD4KMT2A | |
| Hydrochloric Acid SCHEMBL31747485 | 0.80 | MAPK1 (0.47) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12024523-B2 | Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors | ASTRAZENECA AB (SE) | 2024-07-02 | — | — | US | disclosed |
| US-20230219967-A1 | PYRAZOLE DERIVATIVES USEFUL AS 5-LIPOXYGENASE ACTIVATING PROTEIN (FLAP) INHIBITORS | ASTRAZENECA AB (SE) | 2023-07-13 | — | — | US | disclosed |
| US-11691978-B2 | Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors | ASTRAZENECA AB (SE) | 2023-07-04 | — | — | US | disclosed |
| US-20210355127-A1 | PYRAZOLE DERIVATIVES USEFUL AS 5-LIPOXYGENASE ACTIVATING PROTEIN (FLAP) INHIBITORS | ASTRAZENECA AB (SE) | 2021-11-18 | — | — | US | disclosed |
| US-11001589-B2 | Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors | ASTRAZENECA AB (SE) | 2021-05-11 | — | — | US | disclosed |
| US-20200157113-A1 | PYRAZOLE DERIVATIVES USEFUL AS 5-LIPOXYGENASE ACTIVATING PROTEIN (FLAP) INHIBITORS | ASTRAZENECA AB (SE) | 2020-05-21 | — | — | US | disclosed |
| US-20190084991-A1 | PYRAZOLE DERIVATIVES USEFUL AS 5-LIPOXYGENASE ACTIVATING PROTEIN (FLAP) INHIBITORS | ASTRAZENECA AB (SE) | 2019-03-21 | — | — | US | disclosed |
| US-10183947-B2 | Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors | ASTRAZENECA AB (SE) | 2019-01-22 | — | — | US | disclosed |
| CN-103987775-B | Rubber composition and pneumatic tire | 住友橡胶工业株式会社 | 2016-06-22 | — | — | CN | disclosed |
| CN-102731722-B | For the production of the method for modified conjugated diene polymer, modified conjugated diene polymer and polymer composition | SUMITOMO CHEMICAL CO., LTD. (JP) | 2016-03-16 | — | — | CN | disclosed |
| CN-102731722-A | Process for producing modified conjugated diene-based polymer, modified conjugated diene-based polymer, and polymer composition | SUMITOMO CHEMICAL CO | 2012-10-17 | — | — | CN | disclosed |
| US-8148373-B2 | Compounds | ASTRAZENECA AB (SE) | 2012-04-03 | — | — | US | disclosed |
| US-20090298807-A1 | Compounds | ASTRAZENECA AB (SE) | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200157113-A1 | PYRAZOLE DERIVATIVES USEFUL AS 5-LIPOXYGENASE ACTIVATING PROTEIN (FLAP) INHIBITORS | ALOX5, LIPG, ALOX15 | XDH 101/4885ADORA3 2545/4885MAPT 4838/4885 |
| US-20210355127-A1 | PYRAZOLE DERIVATIVES USEFUL AS 5-LIPOXYGENASE ACTIVATING PROTEIN (FLAP) INHIBITORS | ALOX5, LIPG, ALOX15 | XDH 101/4885ADORA3 2545/4885MAPT 4838/4885 |
| US-10183947-B2 | Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors | ALOX5, LIPG, ALOX15 | XDH 101/4885ADORA3 2545/4885MAPT 4838/4885 |
| US-11691978-B2 | Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors | ALOX5, LIPG, ALOX15 | XDH 101/4885ADORA3 2545/4885MAPT 4838/4885 |
| US-20230219967-A1 | PYRAZOLE DERIVATIVES USEFUL AS 5-LIPOXYGENASE ACTIVATING PROTEIN (FLAP) INHIBITORS | ALOX5, LIPG, ALOX15 | XDH 101/4885ADORA3 2545/4885MAPT 4838/4885 |
| US-20190084991-A1 | PYRAZOLE DERIVATIVES USEFUL AS 5-LIPOXYGENASE ACTIVATING PROTEIN (FLAP) INHIBITORS | ALOX5, LIPG, ALOX15 | XDH 101/4885ADORA3 2545/4885MAPT 4838/4885 |
| US-12024523-B2 | Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors | ALOX5, LIPG, ALOX15 | XDH 101/4885ADORA3 2545/4885MAPT 4838/4885 |
| US-11001589-B2 | Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors | ALOX5, LIPG, ALOX15 | XDH 101/4885ADORA3 2545/4885MAPT 4838/4885 |
| US-20090298807-A1 | Compounds | PKD1, SLC10A1, ABCB11 | XDH 1239/4885ADORA3 1418/4885MAPT 3010/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.