Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.49 |
| ▸ | CTSS | P25774 | 4/20 | 0.49 |
| ▸ | CTSL | P07711 | 2/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.45 |
| ▸ | KLK7 | P49862 | 2/20 | 0.45 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.44 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | PTPRA | P18433 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10135741 | 0.89 | CTSK (0.55) | CTSKCTSSCTSLCTSBAKT1 | |
| SCHEMBL14637585 | 0.89 | CTSK (0.55) | CTSKCTSSCTSLCTSBAKT1 | |
| SCHEMBL14684989 | 0.89 | CTSK (0.51) | CTSKCTSSCTSLCTSBAKT1 | |
| SCHEMBL10241806 | 0.88 | CTSS (0.53) | CTSKCTSSCTSLCTSBAKT1 | |
| SCHEMBL18978665 | 0.88 | CTSK (0.53) | CTSKCTSSCTSLCTSBAKT1 | |
| SCHEMBL880800 | 0.86 | CTSK (0.47) | CTSKCTSSCTSLCTSBAKT1 | |
| SCHEMBL13043257 | 0.86 | CTSK (0.56) | CTSKCTSSCTSLCTSBAKT1 | |
| SCHEMBL18978668 | 0.85 | CTSK (0.51) | CTSKCTSSCTSLCTSBAKT1 | |
| SCHEMBL969253 | 0.84 | PAX8 (0.53) | CTSKCTSSCTSLCTSBAKT1 | |
| SCHEMBL10241805 | 0.84 | CTSK (0.53) | CTSKCTSSCTSLCTSBAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101661-B2 | Polar hydrophilic prodrugs and non-standard amino acid conjugates of amphetamine and other stimulants and processes for making and using the same | KEMPHARM, INC. (US) | 2012-01-24 | — | — | US | disclosed |
| US-20110213034-A1 | Polar Hydrophilic Prodrugs of Amphetamine and Other Stimulants and Processes for Making and Using the Same | SHIRE LLC | 2011-09-01 | — | — | US | disclosed |
| US-20100292336-A1 | Polar Hydrophilic Prodrugs and Non-Standard Amino Acid Conjugates of Amphetamine and Other Stimulants and Processes for Making and Using the Same | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-11-18 | — | — | US | disclosed |
| US-7776917-B2 | Non-standard amino acid conjugates of amphetamine and processes for making and using the same | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-17 | — | — | US | disclosed |
| US-7772222-B2 | Polar hydrophilic prodrugs of amphetamine and other stimulants and processes for making and using the same | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-10 | — | — | US | disclosed |
| US-20090234018-A1 | Non-Standard Amino Acid Conjugates of Amphetamine and Processes for Making and Using the Same | SHIRE LLC | 2009-09-17 | — | — | US | disclosed |
| US-20080207757-A1 | Polar Hydrophilic Prodrugs of Amphetamine and Other Stimulants and Processes for Making and Using the Same | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-28 | — | — | US | disclosed |
| US-20080139653-A1 | Non-standard amino acid conjugates of amphetamine and processes for making and using the same | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292336-A1 | Polar Hydrophilic Prodrugs and Non-Standard Amino Acid Conjugates of Amphetamine and Other Stimulants and Processes for Making and Using the Same | SLC18A2, SLC6A19, SLC6A2 | CTSK 3469/4885CTSS 2715/4885CTSL 1564/4885 |
| US-20090234018-A1 | Non-Standard Amino Acid Conjugates of Amphetamine and Processes for Making and Using the Same | SLC6A3, AADAT, SLC6A2 | CTSK 2102/4885CTSS 1682/4885CTSL 1386/4885 |
| US-20080139653-A1 | Non-standard amino acid conjugates of amphetamine and processes for making and using the same | SLC6A3, AADAT, SLC6A2 | CTSK 2102/4885CTSS 1682/4885CTSL 1386/4885 |
| US-20110213034-A1 | Polar Hydrophilic Prodrugs of Amphetamine and Other Stimulants and Processes for Making and Using the Same | SLC6A3, SLC6A2, SLC6A15 | CTSK 3373/4885CTSS 2888/4885CTSL 2019/4885 |
| US-20080207757-A1 | Polar Hydrophilic Prodrugs of Amphetamine and Other Stimulants and Processes for Making and Using the Same | SLC6A2, SLC6A3, SLC18A2 | CTSK 3262/4885CTSS 2420/4885CTSL 1745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.