SCHEMBL10246039

SCHEMBL10246039

O=C(CCCCC1SCC2NC(=O)NC21)NCCOCCOCCOCCOCCC(=O)NCCCCNC(=O)c1cccc(P(c2ccccc2)c2ccccc2)c1

nearest known ligand 0.58

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
FOLH1 Q04609 7/20 0.58
HSP90AB1 P08238 1/20 0.58
NOXO1 Q8NFA2 1/20 0.55
GBA1 P04062 1/20 0.55
PRSS1 P07477 3/20 0.54
PRSS2 P07478 3/20 0.54
PRSS3 P35030 3/20 0.54
TPSAB1 Q15661 3/20 0.54
PKM P14618 2/20 0.54
PLG P00747 2/20 0.54
F2 P00734 2/20 0.54
LY6K Q17RY6 1/20 0.52
L3MBTL3 Q96JM7 1/20 0.52
TDP1 Q9NUW8 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14315660 0.89 FOLH1 (0.55) FOLH1HSP90AB1NOXO1GBA1PRSS1
SCHEMBL10191057 0.88 FOLH1 (0.55) FOLH1HSP90AB1NOXO1GBA1PRSS1
SCHEMBL21008402 0.87 FOLH1 (0.55) FOLH1HSP90AB1NOXO1GBA1PRSS1
SCHEMBL19326743 0.87 FOLH1 (0.58) FOLH1HSP90AB1NOXO1GBA1PRSS1
SCHEMBL13528559 0.85 PKM (0.60) FOLH1HSP90AB1NOXO1GBA1PRSS1
SCHEMBL5806320 0.85 FOLH1 (0.52) FOLH1HSP90AB1NOXO1PRSS1PRSS2
SCHEMBL20519815 0.84 FOLH1 (0.57) FOLH1HSP90AB1NOXO1PRSS1PRSS2
SCHEMBL20520127 0.83 PRSS1 (0.58) FOLH1HSP90AB1NOXO1PRSS1PRSS2
SCHEMBL20519966 0.83 PRSS1 (0.58) FOLH1HSP90AB1NOXO1PRSS1PRSS2
SCHEMBL13986332 0.83 L3MBTL3 (0.52) FOLH1HSP90AB1NOXO1PRSS1PRSS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8114636-B2 Labeling and detection of nucleic acids Life Technologies Corporation (US) 2012-02-14 US disclosed
US-20100261181-A1 LABELING AND DETECTION OF NUCLEIC ACIDS Life Technologies Corporation (US) 2010-10-14 US disclosed
WO-2008029281-A2 LABELING AND DETECTION OF POST TRANSLATIONALLY MODIFIED PROTEINS INVITROGEN CORPORATION (US) 2008-03-13 WO disclosed
US-20080050731-A1 LABELING AND DETECTION OF NUCLEIC ACIDS INVITROGEN CORPORATION (US) 2008-02-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100261181-A1 LABELING AND DETECTION OF NUCLEIC ACIDS RNGTT, ADAR, ALKBH1 FOLH1 1109/4885HSP90AB1 3267/4885NOXO1 1977/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.