Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.61 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.61 |
| ▸ | CHRNA7 | P36544 | 6/20 | 0.59 |
| ▸ | APOBEC3A | P31941 | 3/20 | 0.49 |
| ▸ | APOBEC3G | Q9HC16 | 3/20 | 0.49 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.49 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL724930 | 1.00 | CHRNB2 (0.61) | CHRNB2CHRNA4CHRNA7APOBEC3AAPOBEC3G | |
| Water SCHEMBL723735 | 0.98 | CHRNB2 (0.59) | CHRNB2CHRNA4CHRNA7APOBEC3AAPOBEC3G | |
| Hydrochloric Acid SCHEMBL723900 | 0.98 | CHRNB2 (0.59) | CHRNB2CHRNA4CHRNA7APOBEC3AAPOBEC3G | |
| Bromide SCHEMBL2450495 | 0.98 | CHRNB2 (0.59) | CHRNB2CHRNA4CHRNA7APOBEC3AAPOBEC3G | |
| Iodide SCHEMBL11507837 | 0.98 | CHRNB2 (0.65) | CHRNB2CHRNA4CHRNA7APOBEC3AAPOBEC3G | |
| Water SCHEMBL8939227 | 0.98 | CHRNB2 (0.59) | CHRNB2CHRNA4CHRNA7APOBEC3AAPOBEC3G | |
| SCHEMBL3681307 | 0.98 | CHRNA7 (0.60) | CHRNB2CHRNA4CHRNA7APOBEC3AAPOBEC3G | |
| Water SCHEMBL8939226 | 0.96 | CHRNB2 (0.58) | CHRNB2CHRNA4CHRNA7APOBEC3AAPOBEC3G | |
| Hydrochloric Acid SCHEMBL2458828 | 0.96 | CHRNA7 (0.58) | CHRNB2CHRNA4CHRNA7APOBEC3AAPOBEC3G | |
| Iodide SCHEMBL3691022 | 0.96 | CHRNA7 (0.63) | CHRNB2CHRNA4CHRNA7APOBEC3AAPOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1719768-B1 | NOVEL BENZOTHIAZEPINE AND BENZOTHIEPINE COMPOUNDS | ASAHI KASEI PHARMA CORP (JP) | 2012-04-25 | — | — | EP | disclosed |
| US-20120015925-A1 | NOVEL BENZOTHIAZEPINE AND BENZOTHIEPINE COMPOUNDS | ASAHI KASEI PHARMA CORPORATION (JP) | 2012-01-19 | — | — | US | disclosed |
| EP-1535913-B1 | NOVEL QUATERNARY AMMONIUM COMPOUNDS | ASAHI KASEI PHARMA CORP (JP) | 2011-11-02 | — | — | EP | disclosed |
| US-7973030-B2 | Benzothiazepine and benzothiepine compounds | ASAHI KASEI PHARMA CORPORATION (JP) | 2011-07-05 | — | — | US | disclosed |
| US-7803792-B2 | Quaternary ammonium compounds | ASAHI KASEI PHARMA CORPORATION (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7312208-B2 | Quaternary ammonium compounds | ASAHI KASEI PHARMA CORPORATION (JP) | 2007-12-25 | — | — | US | disclosed |
| US-20070203115-A1 | Novel quaternary ammonium compounds | ASAHI KASEI PHARMA CORPORATION (JP) | 2007-08-30 | — | — | US | disclosed |
| US-20070190041-A1 | Novel benzothiazepine and bensothiepine compounds | ASHAI KASEI PHARAMA CORPORATION (JP) | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203115-A1 | Novel quaternary ammonium compounds | SLC10A2, SLC10A1, ABCB11 | CHRNB2 2528/4885CHRNA4 3536/4885CHRNA7 3399/4885 |
| US-20120015925-A1 | NOVEL BENZOTHIAZEPINE AND BENZOTHIEPINE COMPOUNDS | SLC10A1, SREBF1, SPTLC1 | CHRNB2 4620/4885CHRNA4 3883/4885CHRNA7 3829/4885 |
| US-20070190041-A1 | Novel benzothiazepine and bensothiepine compounds | SLC10A1, GOT1, CES1 | CHRNB2 4564/4885CHRNA4 3309/4885CHRNA7 3152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.