Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
| ▸ | GUSB | P08236 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9956151 | 0.82 | KDM4E (0.42) | TRPM8MAOBNOTUM | |
| SCHEMBL5543913 | 0.81 | TRPM8 (0.43) | TRPM8MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL7624713 | 0.79 | PTGS2 (0.59) | TRPM8MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5543906 | 0.78 | TRPM8 (0.41) | TRPM8MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL31194857 | 0.77 | MAPK13 (0.60) | MAPK13MAPK12MAPK11MAPK14PTGS2 | |
| SCHEMBL6516224 | 0.75 | PTGS2 (0.52) | TRPM8MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL9956413 | 0.75 | NOTUM (0.39) | TRPM8PTGS2PTGS1MGAMGAA | |
| SCHEMBL10263340 | 0.75 | L3MBTL1 (0.45) | TRPM8MGAMGAASIMGAM2 | |
| SCHEMBL1167044 | 0.74 | PIN1 (0.50) | TRPM8 | |
| SCHEMBL6516453 | 0.72 | PTGS2 (0.48) | TRPM8MAPK13MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085852-A1 | 3,8-DIAZA-BICYCLO[4.2.0]OCT-8-YL AMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012085857-A1 | 3,8-DIAZA-BICYCLO[4.2.0]OCT-3-YL AMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-06-28 | — | — | WO | disclosed |