Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAAT3 | P53816 | 1/20 | 0.40 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.40 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.40 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1902599 | 0.76 | SMN1; SMN2 (0.43) | SIGMAR1OPRM1DRD3SMN1; SMN2MEN1 | |
| SCHEMBL9954703 | 0.74 | DRD2 (0.44) | PLAAT3PLAAT5PLAAT2PLAAT4TAAR1 | |
| SCHEMBL11055846 | 0.73 | CYP2C19 (0.48) | TAAR1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1850432 | 0.73 | DRD2 (0.43) | PLAAT3PLAAT5PLAAT2PLAAT4TAAR1 | |
| SCHEMBL992024 | 0.73 | CYP2C19 (0.33) | OPRM1MAPTRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL117417 | 0.71 | SMN1; SMN2 (0.40) | SIGMAR1OPRM1DRD3MAPTSMN1; SMN2 | |
| SCHEMBL11922655 | 0.70 | CYP2C19 (0.39) | TAAR1SIGMAR1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL18380911 | 0.70 | CYP2C19 (0.41) | TAAR1SMN1; SMN2 | |
| SCHEMBL3192627 | 0.69 | SIGMAR1 (0.39) | SIGMAR1OPRM1DRD3MAPTSMN1; SMN2 | |
| SCHEMBL9955077 | 0.69 | POLB (0.46) | PLAAT3PLAAT5PLAAT2PLAAT4MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274287-A1 | INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | Vitae Pharmaceuticals, Inc. (US) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009117109-A1 | INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |