Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT6A | Q92794 | 2/20 | 0.51 |
| ▸ | HTR6 | P50406 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | METAP2 | P50579 | 1/20 | 0.46 |
| ▸ | TNNI3K | Q59H18 | 4/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12217548 | 0.86 | KAT6A (0.49) | KAT6AHTR6L3MBTL1METAP2TNNI3K | |
| SCHEMBL28049651 | 0.85 | CYP4F2 (0.47) | HTR6L3MBTL1TNNI3KEGFRALDH1A1 | |
| SCHEMBL12630230 | 0.82 | ALDH1A1 (0.51) | HTR6L3MBTL1ALDH1A1POLB | |
| SCHEMBL27876496 | 0.82 | HTR6 (0.61) | KAT6AHTR6METAP2ALDH1A1GAA | |
| SCHEMBL10213284 | 0.81 | LMNA (0.45) | HTR6L3MBTL1TNNI3KEGFRALDH1A1 | |
| SCHEMBL8277423 | 0.81 | KEAP1 (0.65) | KAT6AL3MBTL1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL3060871 | 0.81 | L3MBTL1 (0.47) | HTR6L3MBTL1TNNI3KEGFRALDH1A1 | |
| SCHEMBL5293352 | 0.81 | IKBKB (0.48) | L3MBTL1TNNI3KEGFRALDH1A1GAA | |
| SCHEMBL1014348 | 0.81 | HTR6 (0.55) | HTR6L3MBTL1TNNI3KEGFRGAA | |
| SCHEMBL22070843 | 0.81 | L3MBTL1 (0.47) | HTR6L3MBTL1TNNI3KEGFRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120088758-A1 | FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088758-A1 | FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | F12, F11, F5 | KAT6A 2581/4885HTR6 3071/4885L3MBTL1 2920/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.