Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9929081 | 0.90 | ALDH1A1 (0.50) | MEN1KMT2ANPC1SIGMAR1POLB | |
| SCHEMBL9928824 | 0.83 | SIGMAR1 (0.47) | MEN1KMT2ANPC1SIGMAR1POLB | |
| SCHEMBL10278605 | 0.76 | NPC1 (0.50) | MEN1KMT2ANPC1SIGMAR1POLB | |
| SCHEMBL4472638 | 0.76 | MEN1 (0.64) | MEN1KMT2ANPC1SIGMAR1POLB | |
| SCHEMBL23213781 | 0.74 | ALDH1A1 (0.56) | MEN1KMT2ANPC1POLBALDH1A1 | |
| SCHEMBL20254958 | 0.74 | PKM (0.47) | MEN1KMT2ANPC1POLBALDH1A1 | |
| SCHEMBL29688741 | 0.74 | PKM (0.47) | MEN1KMT2ANPC1POLBALDH1A1 | |
| SCHEMBL14364105 | 0.74 | THRB (0.56) | MEN1KMT2ANPC1POLBALDH1A1 | |
| SCHEMBL14753937 | 0.73 | TSHR (0.46) | MEN1KMT2ANPC1POLBALDH1A1 | |
| SCHEMBL999447 | 0.73 | ALDH1A1 (0.53) | MEN1KMT2ANPC1POLBSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3660016-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Holdings Corporation (US) | 2020-06-03 | — | — | EP | disclosed |
| EP-2655374-B1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE HOLDINGS CORP (US) | 2019-10-23 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |