SCHEMBL10285705

SCHEMBL10285705

Cc1nc2cccc(OCC(C)(C)NC(=O)[C@H]3CC[C@H](O)CC3)c2c(N)c1C(=O)O

nearest known ligand 0.40

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
SSTR4 P31391 17/20 0.40
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
GAA P10253 1/20 0.34
HPGD P15428 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10259335 1.00 SSTR4 (0.40) SSTR4MEN1KMT2AKDM4EALDH1A1
SCHEMBL10257618 1.00 SSTR4 (0.40) SSTR4MEN1KMT2AKDM4EALDH1A1
SCHEMBL15605504 0.96 SSTR4 (0.42) SSTR4MEN1KMT2A
SCHEMBL27103197 0.93 SSTR4 (0.40) SSTR4MEN1KMT2AKDM4E
SCHEMBL627378 0.93 SSTR4 (0.41) SSTR4MEN1KMT2A
SCHEMBL618830 0.93 SSTR4 (0.41) SSTR4MEN1KMT2A
SCHEMBL621093 0.92 SSTR4 (0.40) SSTR4MEN1KMT2AGAA
SCHEMBL620982 0.90 DHFR (0.40) SSTR4MEN1KMT2A
SCHEMBL10257800 0.90 SSTR4 (0.42) SSTR4KDM4EALDH1A1
SCHEMBL18117489 0.89 SSTR4 (0.38) SSTR4MEN1KMT2AKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2603098-B1 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER FIRMENICH INCORPORATED (US) 2025-08-06 EP disclosed
US-11129397-B2 Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer FIREMENICH INCORPORATED (US) 2021-09-28 US disclosed
US-20190208802-A1 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER FIRMENICH INCORPORATED 2019-07-11 US disclosed
US-10244779-B2 Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer SENOMYX, INC. (US) 2019-04-02 US disclosed
US-10244779-B2 Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer SENOMYX, INC. (US) 2019-04-02 US disclosed
US-9834544-B2 Sweet flavor modifier SENOMYX, INC. (US) 2017-12-05 US disclosed
EP-2742026-B1 SWEET FLAVOR MODIFIER SENOMYX INC (US) 2016-10-05 EP disclosed
EP-2742026-B1 SWEET FLAVOR MODIFIER SENOMYX INC (US) 2016-10-05 EP disclosed
US-20150245642-A1 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER FIRMENICH INCORPORATED 2015-09-03 US disclosed
US-20150141527-A1 SWEET FLAVOR MODIFIER FIRMENICH INCORPORATED 2015-05-21 US disclosed
US-9000054-B2 Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer SENOMYX, INC. (US) 2015-04-07 US disclosed
US-8815956-B2 Sweet flavor modifier SENOMYX, INC. (US) 2014-08-26 US disclosed
WO-2013025560-A1 SWEET FLAVOR MODIFIER SENOMYX, INC. (US) 2013-02-21 WO disclosed
US-20130041046-A1 SWEET FLAVOR MODIFIER SENOMYX, INC. (US) 2013-02-14 US disclosed
US-20120041078-A1 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER SENOMYX, INC. (US) 2012-02-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10244779-B2 Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer TFEB, TREH, SLC2A8 SSTR4 2147/4885MEN1 2269/4885KMT2A 740/4885
US-20120041078-A1 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER TFEB, TREH, SLC2A8 SSTR4 2147/4885MEN1 2269/4885KMT2A 740/4885
US-20150245642-A1 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER TFEB, TREH, SLC2A8 SSTR4 2147/4885MEN1 2269/4885KMT2A 740/4885
US-20130041046-A1 SWEET FLAVOR MODIFIER TAS2R5, TAS2R10, TAS2R50 SSTR4 764/4885MEN1 1566/4885KMT2A 1894/4885
US-11129397-B2 Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer TFEB, TREH, SLC2A8 SSTR4 2147/4885MEN1 2269/4885KMT2A 740/4885
US-20150141527-A1 SWEET FLAVOR MODIFIER TAS2R5, TAS2R10, TAS2R50 SSTR4 764/4885MEN1 1566/4885KMT2A 1894/4885
US-20190208802-A1 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER TFEB, TREH, SLC2A8 SSTR4 2147/4885MEN1 2269/4885KMT2A 740/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.