Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A1 | P30531 | 1/20 | 0.36 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.36 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 2/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10287957 | 0.94 | SIGMAR1 (0.37) | SLC6A1SLC6A12SLC6A11ALDH1A1LMNA | |
| SCHEMBL12121683 | 0.93 | SIGMAR1 (0.38) | SLC6A1SLC6A12SLC6A11ALDH1A1LMNA | |
| SCHEMBL10288236 | 0.93 | ALDH1A1 (0.41) | SLC6A1SLC6A12SLC6A11ALDH1A1LMNA | |
| SCHEMBL10287526 | 0.91 | CCR1 (0.35) | SLC6A1SLC6A12SLC6A11ALDH1A1LMNA | |
| SCHEMBL13824429 | 0.91 | ALDH1A1 (0.39) | SLC6A1SLC6A12SLC6A11ALDH1A1LMNA | |
| SCHEMBL12121526 | 0.91 | SIGMAR1 (0.34) | SLC6A1SLC6A12SLC6A11ALDH1A1LMNA | |
| SCHEMBL13617254 | 0.91 | DRD2 (0.36) | SLC6A1SLC6A12SLC6A11ALDH1A1LMNA | |
| SCHEMBL12121525 | 0.90 | SIGMAR1 (0.35) | SLC6A1SLC6A12SLC6A11ALDH1A1LMNA | |
| SCHEMBL13617238 | 0.87 | SLC6A1 (0.37) | SLC6A1SLC6A12SLC6A11ALDH1A1LMNA | |
| SCHEMBL13617243 | 0.86 | CCR1 (0.34) | SLC6A1SLC6A12SLC6A11ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046311-A1 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2012-02-23 | — | — | US | disclosed |
| US-7541365-B2 | Chemokine receptor antagonists and methods of use therefor | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046311-A1 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF | ACKR3, CCR2, CXCR2 | SLC6A1 1194/4885SLC6A12 1558/4885SLC6A11 1474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.