Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.51 |
| ▸ | FEN1 | P39748 | 4/20 | 0.50 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | NNMT | P40261 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.40 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.40 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.40 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12843365 | 0.82 | FEN1 (0.53) | ASIC3FEN1ALOX5APGRM5PIK3C3 | |
| SCHEMBL8385558 | 0.80 | ASIC3 (0.61) | ASIC3FEN1ALOX5APGRM5PIK3C3 | |
| SCHEMBL8389157 | 0.77 | ASIC3 (0.58) | ASIC3FEN1ALOX5APGRM5PIK3C3 | |
| SCHEMBL15730767 | 0.76 | FEN1 (0.45) | ASIC3FEN1ALOX5APGRM5PIK3C3 | |
| SCHEMBL16195363 | 0.76 | CYP11B2 (0.52) | ASIC3FEN1ALOX5APPIK3C3NNMT | |
| SCHEMBL12843362 | 0.76 | ASIC3 (0.54) | ASIC3FEN1ALOX5APGRM5PIK3C3 | |
| SCHEMBL31504068 | 0.74 | GRIA1 (0.56) | CD274GRIA1CACNG8NISCHTRPA1 | |
| SCHEMBL13004738 | 0.73 | ASIC3 (0.58) | ASIC3FEN1ALOX5APGRM5PIK3C3 | |
| SCHEMBL8385317 | 0.73 | ASIC3 (0.57) | ASIC3FEN1ALOX5APGRM5PIK3C3 | |
| SCHEMBL828125 | 0.72 | NNMT (0.53) | ASIC3FEN1ALOX5APGRM5PIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120053177-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2012-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053177-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | MAP3K20, MAP3K13, MAP3K8 | ASIC3 4358/4885FEN1 2321/4885ALOX5AP 4050/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.