Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | MGLL | Q99685 | 3/20 | 0.50 |
| ▸ | SLC18A3 | Q16572 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1029934 | 0.88 | ALDH1A1 (0.56) | ALDH1A1LMNAPOLBMGLLSLC18A3 | |
| SCHEMBL1031081 | 0.87 | ALDH1A1 (0.48) | ALDH1A1LMNAPOLBMGLLSMN1; SMN2 | |
| SCHEMBL1031944 | 0.78 | GHSR (0.46) | ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL1031573 | 0.78 | KMT2A (0.52) | ALDH1A1LMNAKMT2AHSD11B1MEN1 | |
| SCHEMBL1028175 | 0.78 | TP53 (0.52) | ALDH1A1LMNAPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL1720550 | 0.76 | POLB (0.89) | ALDH1A1LMNAPOLBMGLLSLC18A3 | |
| SCHEMBL6210853 | 0.76 | POLB (0.89) | ALDH1A1LMNAPOLBMGLLSLC18A3 | |
| SCHEMBL1031811 | 0.75 | HPGD (0.54) | ALDH1A1LMNAPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL1033202 | 0.74 | KCNA5 (0.46) | ALDH1A1LMNAPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL1028655 | 0.74 | KCNA5 (0.44) | ALDH1A1LMNAKMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | claimed |