Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.52 |
| ▸ | MEN1 | O00255 | 7/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1030367 | 0.87 | KMT2A (0.48) | KMT2AMEN1LMNAHSD11B1ALDH1A1 | |
| SCHEMBL1029484 | 0.82 | HSD11B1 (0.47) | HSD11B1ALDH1A1 | |
| SCHEMBL1030828 | 0.79 | MAPT (0.47) | KMT2AMEN1LMNAALDH1A1MAPT | |
| SCHEMBL1031081 | 0.79 | ALDH1A1 (0.48) | LMNAALDH1A1TP53 | |
| SCHEMBL1029933 | 0.78 | ALDH1A1 (0.58) | KMT2AMEN1LMNAHSD11B1ALDH1A1 | |
| SCHEMBL1031510 | 0.75 | MEN1 (0.51) | KMT2AMEN1 | |
| SCHEMBL1028175 | 0.74 | TP53 (0.52) | KMT2AMEN1LMNAALDH1A1MAPT | |
| SCHEMBL1031811 | 0.74 | HPGD (0.54) | KMT2AMEN1LMNAALDH1A1MAPT | |
| SCHEMBL1034078 | 0.73 | MAPT (0.46) | KMT2AMEN1LMNAALDH1A1MAPT | |
| SCHEMBL1033202 | 0.71 | KCNA5 (0.46) | KMT2AMEN1LMNAALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | claimed |