Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.38 |
| ▸ | EIF4E | P06730 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.36 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12825647 | 0.94 | KMT2A (0.34) | MKNK1MKNK2EIF4EHPGDKDM4E | |
| SCHEMBL10299320 | 0.92 | POLB (0.41) | HPGDKDM4EALDH1A1HSD17B10POLB | |
| SCHEMBL10299318 | 0.88 | MKNK1 (0.36) | MKNK1MKNK2EIF4EHPGDKDM4E | |
| SCHEMBL10003784 | 0.86 | HTR3A (0.45) | HPGDKDM4EALDH1A1HSD17B10POLB | |
| SCHEMBL12019564 | 0.86 | CXCR3 (0.34) | ALDH1A1BRPF1PIK3CB | |
| SCHEMBL10299336 | 0.86 | LMNA (0.35) | HPGDALDH1A1POLBSMOPIK3CB | |
| SCHEMBL10299326 | 0.86 | AHR (0.40) | ALDH1A1POLBTP53MAPT | |
| SCHEMBL12020094 | 0.85 | SMO (0.36) | HPGDALDH1A1SMOTP53MAPT | |
| SCHEMBL10299353 | 0.84 | ALDH1A1 (0.42) | HPGDKDM4EALDH1A1HSD17B10POLB | |
| SCHEMBL10003727 | 0.83 | HKDC1 (0.37) | HPGDKDM4EALDH1A1SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8907089-B2 | Fused heterocyclic ring derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-12-09 | — | — | US | disclosed |
| EP-2471790-A1 | FUSED HETEROCYCLIC RING DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-07-04 | — | — | EP | disclosed |