Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.55 |
| ▸ | LMNA | P02545 | 6/20 | 0.55 |
| ▸ | HTT | P42858 | 4/20 | 0.55 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1029226 | 0.88 | MEN1 (0.57) | MEN1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL1029484 | 0.82 | HSD11B1 (0.47) | ALDH1A1PKML3MBTL1THRB | |
| SCHEMBL1031510 | 0.81 | MEN1 (0.51) | MEN1KMT2APRKAA2 | |
| SCHEMBL1030828 | 0.78 | MAPT (0.47) | MEN1KMT2ACYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL1034078 | 0.77 | MAPT (0.46) | MEN1KMT2ASMN1; SMN2LMNAHTT | |
| SCHEMBL1028175 | 0.75 | TP53 (0.52) | MEN1KMT2ASMN1; SMN2LMNAHTT | |
| SCHEMBL1032620 | 0.74 | HTT (0.53) | MEN1KMT2ASMN1; SMN2LMNAHTT | |
| SCHEMBL1031811 | 0.73 | HPGD (0.54) | MEN1KMT2AKDM4ESMN1; SMN2LMNA | |
| SCHEMBL1031573 | 0.70 | KMT2A (0.52) | MEN1KMT2ALMNAALDH1A1MAPT | |
| SCHEMBL1029485 | 0.70 | HSD11B1 (0.46) | ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | claimed |