Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1029484 | 0.91 | HSD11B1 (0.47) | ALDH1A1THRBRXFP1 | |
| SCHEMBL1028758 | 0.84 | GRIN2B (0.44) | MAPTALDH1A1SMN1; SMN2MAPK1MEN1 | |
| SCHEMBL1031510 | 0.83 | MEN1 (0.51) | MEN1KMT2A | |
| SCHEMBL1031811 | 0.82 | HPGD (0.54) | MAPTPOLBALDH1A1HPGDLMNA | |
| SCHEMBL1034078 | 0.81 | MAPT (0.46) | MAPTPOLBGAAALDH1A1LMNA | |
| SCHEMBL1028175 | 0.80 | TP53 (0.52) | MAPTPOLBALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL1031573 | 0.79 | KMT2A (0.52) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL1030438 | 0.78 | MEN1 (0.61) | MAPTPOLBALDH1A1CYP2C19CYP2C9 | |
| SCHEMBL1032620 | 0.78 | HTT (0.53) | MAPTPOLBALDH1A1HPGDLMNA | |
| SCHEMBL1029485 | 0.77 | HSD11B1 (0.46) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | claimed |