Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | TP53 | P04637 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.47 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.47 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.47 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.47 |
| ▸ | ESRRG | P62508 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1033446 | 0.83 | NPC1 (0.53) | NPC1RAB9ATP53MAPTPLAAT3 | |
| SCHEMBL1032961 | 0.81 | NPC1 (0.52) | NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL1032781 | 0.76 | MMP13 (0.54) | MAPTSMN1; SMN2 | |
| SCHEMBL1081685 | 0.76 | NPSR1 (0.60) | KMT2A | |
| SCHEMBL1029403 | 0.76 | NAMPT (0.45) | TP53MAPTHPGDSMN1; SMN2 | |
| SCHEMBL1032170 | 0.75 | RIPK1 (0.47) | MAPT | |
| SCHEMBL1030364 | 0.75 | MCHR1 (0.47) | NPC1RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL5969191 | 0.73 | RAB9A (0.88) | NPC1RAB9ATP53MAPTPLAAT3 | |
| SCHEMBL1031804 | 0.73 | ALDH1A1 (0.42) | TP53KMT2ASMN1; SMN2 | |
| SCHEMBL1081579 | 0.73 | GRIA4 (0.47) | NPC1RAB9ATP53MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | claimed |