Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 4/20 | 0.41 |
| ▸ | PI4K2B | Q8TCG2 | 4/20 | 0.41 |
| ▸ | PI4K2A | Q9BTU6 | 4/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.41 |
| ▸ | CFTR | P13569 | 2/20 | 0.41 |
| ▸ | XDH | P47989 | 5/20 | 0.38 |
| ▸ | DPP4 | P27487 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10275484 | 0.82 | KIF11 (0.46) | PI4KAPI4K2BPI4K2API4KBCFTR | |
| SCHEMBL10313630 | 0.76 | PI4KA (0.40) | PI4KAPI4K2BPI4K2API4KBCFTR | |
| SCHEMBL10313632 | 0.76 | XDH (0.47) | XDH | |
| SCHEMBL10313883 | 0.71 | KIF11 (0.43) | XDHADORA3ADORA2A | |
| SCHEMBL10313641 | 0.70 | XDH (0.42) | XDHADORA3ADORA2A | |
| SCHEMBL19820583 | 0.68 | CHKA (0.45) | PI4KAPI4K2BPI4K2API4KBADORA3 | |
| SCHEMBL13019483 | 0.67 | KIF11 (0.54) | — | |
| SCHEMBL10313636 | 0.65 | MAPK14 (0.36) | PI4KAPI4K2BPI4K2API4KBCFTR | |
| SCHEMBL323825 | 0.65 | ALDH1A1 (0.43) | — | |
| SCHEMBL15756669 | 0.65 | CDK1 (0.50) | PI4KAPI4K2BPI4K2API4KBADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | XU LIFENG (US) | 2012-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | TYMP, TYMS, ADORA3 | PI4KA 2350/4885PI4K2B 3385/4885PI4K2A 3326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.