Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 5/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.41 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.41 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.41 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8346898 | 0.97 | ALDH1A1 (0.42) | ALDH1A1TSHRKIF11HTR3EHTR3B | |
| SCHEMBL13019483 | 0.93 | KIF11 (0.54) | ALDH1A1TSHRKIF11CA1CA2 | |
| SCHEMBL12204495 | 0.84 | PDE2A (0.46) | ALDH1A1CES2CES1 | |
| SCHEMBL12204402 | 0.84 | PDE2A (0.46) | ALDH1A1CES2CES1 | |
| SCHEMBL12204497 | 0.84 | PDE2A (0.46) | ALDH1A1CES2CES1 | |
| SCHEMBL10105694 | 0.77 | PDE2A (0.47) | — | |
| SCHEMBL63468 | 0.76 | ALDH1A1 (0.67) | ALDH1A1TSHRKIF11HTR3EHTR3B | |
| SCHEMBL409015 | 0.76 | HDAC3 (0.32) | — | |
| SCHEMBL12710375 | 0.75 | PDE2A (0.45) | — | |
| SCHEMBL260172 | 0.74 | ALDH1A1 (0.43) | ALDH1A1TSHRKIF11HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118206490-B | Indazole-3-carboxylic acid derivative with antitumor activity, preparation method and application | 国王医学科技(山东)有限公司 | 2024-11-15 | — | — | CN | claimed |
| CN-118206490-A | Indazole-3-carboxylic acid derivative with antitumor activity, preparation method and application | 国王医学科技(山东)有限公司 | 2024-06-18 | — | — | CN | claimed |
| CN-118206490-B | Indazole-3-carboxylic acid derivative with antitumor activity, preparation method and application | 国王医学科技(山东)有限公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-118206490-A | Indazole-3-carboxylic acid derivative with antitumor activity, preparation method and application | 国王医学科技(山东)有限公司 | 2024-06-18 | — | — | CN | disclosed |
| CN-116783195-A | N-phenylaminocarbonyl pyridinyl-, pyrimidinyl and benzo-tropanes as modulators of GPR65 | 帕蒂奥斯治疗有限公司 | 2023-09-19 | — | — | CN | disclosed |
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| US-9750719-B2 | Tetrazole compounds as calcium channel blockers | Convergence Pharmaceuticals Limited (GB) | 2017-09-05 | — | — | US | disclosed |
| US-9403753-B2 | Dual site catalyst for mild, selective nitrile reduction | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2016-08-02 | — | — | US | disclosed |
| EP-3045457-A1 | SUBSTITUTED PYRIMIDINYLPYRROLOPYRIDINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2016-07-20 | — | — | EP | disclosed |
| US-20160145193-A1 | DUAL SITE CATALYST FOR MILD, SELECTIVE NITRILE REDUCTION | NATIONAL SCIENCE FOUNDATION | 2016-05-26 | — | — | US | disclosed |
| US-20160015687-A1 | TETRAZOLE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | Convergence Pharmaceuticals Limited (GB) | 2016-01-21 | — | — | US | disclosed |
| US-20040063947-A1 | Novel intermediates in the synthesis of camptothecin and related compounds and synthesis thereof | UNIVERSITY OF PITTSBURGH | 2004-04-01 | — | — | US | disclosed |
| US-6620937-B2 | Annulation, cyclization | UNIVERSITY OF PITTSBURGH | 2003-09-16 | — | — | US | disclosed |
| US-6376676-B1 | CAPROLACTAM COMPOUND | UNIVERSITY OF PITTSBURGH | 2002-04-23 | — | — | US | disclosed |
| US-20010029298-A1 | Novel intermediates in the synthesis of camptothecin and related compounds and synthesis thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2001-10-11 | — | — | US | disclosed |
| US-6252079-B1 | CYCLIZATION OF CHEMICAL INTERMEDIATE; REACTING WITH ARYL ISONITRILE | UNIVERSITY OF PITTSBURGH | 2001-06-26 | — | — | US | disclosed |
| US-6239278-B1 | Intermediates in the synthesis of (±)-camptothecin and related compounds and synthesis thereof | UNIVERSITY OF PITTSBURGH | 2001-05-29 | — | — | US | disclosed |
| US-6211371-B1 | REACTING AN ARYL ISONIRILE WITH AN ISOQUINOLIN-1-ONE COMPOUND | UNIVERSITY OF PITTSBURGH | 2001-04-03 | — | — | US | disclosed |
| US-6034243-A | Intermediates in the synthesis of (±)-camptothecin and related compounds and synthesis thereof | UNIVERSITY OF PITTSBURGH (US) | 2000-03-07 | — | — | US | disclosed |
| US-5744605-A | ANNULATION; CYCLIZATION | UNIVERSITY OF PITTSBURGH (US) | 1998-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160145193-A1 | DUAL SITE CATALYST FOR MILD, SELECTIVE NITRILE REDUCTION | KMO, FES, TDO2 | ALDH1A1 4832/4885TSHR 2319/4885KIF11 3885/4885 |
| US-20040063947-A1 | Novel intermediates in the synthesis of camptothecin and related compounds and synthesis thereof | CGAS, APEX1, DHPS | ALDH1A1 633/4885TSHR 3838/4885KIF11 3363/4885 |
| US-20010029298-A1 | Novel intermediates in the synthesis of camptothecin and related compounds and synthesis thereof | CGAS, APEX1, DHPS | ALDH1A1 633/4885TSHR 3838/4885KIF11 3363/4885 |
| US-20160015687-A1 | TETRAZOLE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | CACNA1G, CACNA1I, CACNB2 | ALDH1A1 2584/4885TSHR 2720/4885KIF11 2552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.