Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.47 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13077134 | 0.85 | SMN1; SMN2 (0.50) | SIGMAR1SMN1; SMN2KMT2AATMOPRD1 | |
| SCHEMBL6813612 | 0.77 | CYP2D6 (0.50) | SIGMAR1SLC6A4SLC6A2MEN1KMT2A | |
| SCHEMBL3245792 | 0.77 | SMN1; SMN2 (0.46) | SMN1; SMN2ATMOPRD1 | |
| SCHEMBL7288783 | 0.76 | SIGMAR1 (0.56) | SIGMAR1SLC6A4SLC6A2MEN1KMT2A | |
| SCHEMBL8305313 | 0.75 | OPRK1 (0.57) | KDM4EOPRD1 | |
| SCHEMBL8305310 | 0.75 | OPRK1 (0.57) | KDM4EOPRD1 | |
| SCHEMBL3237722 | 0.75 | GAA (0.50) | SIGMAR1SMN1; SMN2SLC6A3 | |
| SCHEMBL8305793 | 0.74 | ALDH1A1 (0.63) | SIGMAR1SLC6A4SLC6A2MEN1KMT2A | |
| SCHEMBL3731169 | 0.74 | OPRD1 (0.46) | SIGMAR1SLC6A4MEN1KMT2AKDM4E | |
| SCHEMBL3239907 | 0.74 | MEN1 (0.44) | SMN1; SMN2MEN1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2475643-A1 | NOVEL ETHANE DIAMINE HEPCIDIN ANTAGONISTS | VIFOR (INTERNATIONAL) AG (CH) | 2012-07-18 | — | — | EP | disclosed |