Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13077134 | 0.88 | SMN1; SMN2 (0.50) | CYP2D6CYP1A2CYP2C19ATMOPRK1 | |
| SCHEMBL3245792 | 0.86 | SMN1; SMN2 (0.46) | CYP2D6CYP2C19ATMOPRK1ALDH1A1 | |
| SCHEMBL11969235 | 0.83 | LMNA (0.53) | TDP1OPRK1KDM4EALDH1A1OPRM1 | |
| SCHEMBL8091287 | 0.79 | L3MBTL1 (0.57) | CYP2D6CYP1A2CYP2C19ATML3MBTL1 | |
| SCHEMBL13039125 | 0.77 | PDE8B (0.46) | CYP2D6CYP1A2CYP2C19ATMOPRK1 | |
| SCHEMBL17765072 | 0.77 | ALDH1A1 (0.45) | CYP2D6CYP2C19ATML3MBTL1OPRK1 | |
| SCHEMBL10316558 | 0.77 | SIGMAR1 (0.50) | ATML3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL8716789 | 0.76 | POLB (0.49) | CYP2D6CYP1A2CYP2C19NTSR1KDM4E | |
| SCHEMBL9130649 | 0.76 | POLB (0.49) | CYP2D6CYP1A2CYP2C19NTSR1KDM4E | |
| SCHEMBL3237722 | 0.76 | GAA (0.50) | CYP2D6OPRM1CHRM2ADRA2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089965-B1 | Urea derivatives for pain management | ASTRAZENECA AB (SE) | 2004-09-15 | — | — | EP | disclosed |
| US-6777561-B1 | MANAGEMENT OF PAIN; PHENYL-UREA COMPOUNDS | ASTRAZENECA CANADA INC. (CA) | 2004-08-17 | — | — | US | disclosed |