Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1048091 | 0.81 | ALDH1A1 (0.53) | RAB9AALDH1A1SMN1; SMN2HPGDTP53 | |
| SCHEMBL1032474 | 0.78 | NPC1 (0.44) | NPC1RAB9AALDH1A1KMT2AMEN1 | |
| SCHEMBL1031481 | 0.78 | THRB (0.53) | NPC1RAB9AKMT2ASMN1; SMN2TP53 | |
| SCHEMBL1028264 | 0.76 | CACNA1G (0.47) | NPSR1KMT2AMEN1FAAHACHE | |
| SCHEMBL1033446 | 0.76 | NPC1 (0.53) | NPC1RAB9AALDH1A1KMT2AMEN1 | |
| SCHEMBL1030734 | 0.76 | CNR1 (0.45) | NPC1ALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL1028724 | 0.74 | POLB (0.51) | NPC1RAB9AALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL1033737 | 0.74 | NPC1 (0.49) | NPC1RAB9ARECQLALDH1A1KMT2A | |
| SCHEMBL2638817 | 0.74 | NOTUM (0.48) | ALDH1A1SMN1; SMN2TSHRHPGDTP53 | |
| SCHEMBL1031690 | 0.74 | HPGD (0.46) | NPC1RAB9AALDH1A1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | claimed |