Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | NOS1 | P29475 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SPR | P35270 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14914554 | 0.83 | ST14 (0.47) | CYP2D6LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL7871359 | 0.80 | MTNR1A (0.49) | MTNR1AMTNR1BNOS1CYP2D6NOS3 | |
| SCHEMBL2811627 | 0.79 | ALDH1A1 (0.52) | NOS1CYP2D6NOS3NOS2LMNA | |
| Bromide SCHEMBL2811699 | 0.78 | ALDH1A1 (0.50) | NOS1CYP2D6NOS3NOS2LMNA | |
| SCHEMBL10591303 | 0.72 | KDM4E (0.66) | MTNR1AMTNR1BLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL22827196 | 0.71 | HDAC3 (0.52) | LMNASMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL3926078 | 0.71 | DRD2 (0.55) | NOS1CYP2D6NOS3NOS2LMNA | |
| SCHEMBL3926060 | 0.69 | TAAR1 (0.57) | NOS1NOS3LMNAALDH1A1TAAR1 | |
| SCHEMBL21556969 | 0.69 | TAAR1 (0.57) | NOS1CYP2D6NOS3NOS2NPC1 | |
| SCHEMBL15139083 | 0.69 | F10 (0.47) | NOS1CYP2D6NOS3NOS2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9090589-B2 | Specific nNOS inhibitors for the therapy and prevention of human melanoma | NORTHWESTERN UNIVERSITY (US) | 2015-07-28 | — | — | US | disclosed |
| US-20140147920-A1 | Specific nNOS Inhibitors for the Therapy and Prevention of Human Melanoma | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-05-29 | — | — | US | disclosed |
| US-8642282-B2 | Inhibitors of nitric oxide synthase for treatment of melanoma | NORTHWESTERN UNIVERSITY (US) | 2014-02-04 | — | — | US | disclosed |
| US-20120238016-A1 | Specific nNOS Inhibitors for the Therapy And Prevention Of Human Melanoma | NORTHWESTERN UNIVERSITY | 2012-09-20 | — | — | US | disclosed |
| WO-2012097121-A2 | SPECIFIC NNOS INHIBITORS FOR THE THERAPY AND PREVENTION OF HUMAN MELANOMA | NORTHWESTERN UNIVERSITY (US) | 2012-07-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140147920-A1 | Specific nNOS Inhibitors for the Therapy and Prevention of Human Melanoma | NOS3, NOS1, NOS2 | MTNR1A 192/4885MTNR1B 272/4885NOS1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.