Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 5/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.45 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.41 |
| ▸ | ACLY | P53396 | 3/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CD38 | P28907 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10328518 | 0.82 | PKM (0.43) | — | |
| SCHEMBL1592031 | 0.81 | AXL (0.47) | NR1H2NR1H3SLC40A1ACLYHSD11B1 | |
| SCHEMBL1591383 | 0.75 | AXL (0.48) | NR1H2NR1H3SLC40A1ACLYCKS1B | |
| SCHEMBL10328535 | 0.74 | AXL (0.45) | SLC40A1ACLYCKS1BSKP2 | |
| SCHEMBL1591670 | 0.71 | AXL (0.49) | NR1H2NR1H3SLC40A1 | |
| SCHEMBL10328531 | 0.69 | KEAP1 (0.47) | SLC40A1GLO1 | |
| SCHEMBL17849564 | 0.69 | ACLY (0.59) | ACLY | |
| SCHEMBL10328514 | 0.68 | ACLY (0.45) | SLC40A1ACLYGLO1 | |
| SCHEMBL1590952 | 0.68 | AXL (0.46) | AGTR1 | |
| SCHEMBL1591247 | 0.68 | AXL (0.52) | NR1H2NR1H3SLC40A1CKS1BSKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262772-B1 | QUINOLINE DERIVATIVES AS AXL KINASE INHIBITORS | MAX PLANCK GESELLSCHAFT (DE) | 2012-07-18 | — | — | EP | disclosed |