Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 2/20 | 0.45 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.39 |
| ▸ | KIT | P10721 | 2/20 | 0.39 |
| ▸ | FRK | P42685 | 1/20 | 0.39 |
| ▸ | SIK1 | P57059 | 1/20 | 0.39 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | SRMS | Q9H3Y6 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.38 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SGK1 | O00141 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10328531 | 0.85 | KEAP1 (0.47) | GLO1SLC40A1BRAFMAP3K20KIT | |
| SCHEMBL10328535 | 0.85 | AXL (0.45) | ACLYSLC40A1KITPGRCCR1 | |
| SCHEMBL10328534 | 0.82 | AGTR1 (0.44) | ACLYMAPTCCR1CCR2CCR4 | |
| SCHEMBL1591689 | 0.81 | AXL (0.53) | ACLYGLO1SLC40A1CRBNPGR | |
| SCHEMBL10328495 | 0.79 | TP53 (0.43) | MAPTCCR2 | |
| SCHEMBL10328491 | 0.77 | AXL (0.55) | ACLYGLO1SLC40A1BRAFMAP3K20 | |
| SCHEMBL10328523 | 0.75 | PGR (0.47) | PGRMAP2K4MAPTPTPN2PTPN1 | |
| SCHEMBL10320336 | 0.72 | AXL (0.47) | ACLYPGRTRIM24PIK3CDGPR119 | |
| SCHEMBL13667269 | 0.69 | RORC (0.52) | KIT | |
| SCHEMBL10328532 | 0.68 | NR1H2 (0.45) | ACLYGLO1SLC40A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262772-B1 | QUINOLINE DERIVATIVES AS AXL KINASE INHIBITORS | MAX PLANCK GESELLSCHAFT (DE) | 2012-07-18 | — | — | EP | disclosed |