Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.42 |
| ▸ | CKS1B | P61024 | 2/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.40 |
| ▸ | PI4KA | P42356 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10328531 | 0.86 | KEAP1 (0.47) | AXLSLC40A1MEN1KMT2ALMNA | |
| SCHEMBL10328514 | 0.85 | ACLY (0.45) | AXLSLC40A1ACLYPGRKIT | |
| SCHEMBL10328534 | 0.83 | AGTR1 (0.44) | MEN1KMT2AACLYLMNACCR1 | |
| SCHEMBL1590938 | 0.81 | AXL (0.63) | AXLCLK1SLC40A1CKS1BSKP2 | |
| SCHEMBL10328495 | 0.80 | TP53 (0.43) | MEN1KMT2AGAANPSR1LMNA | |
| SCHEMBL10328523 | 0.76 | PGR (0.47) | MEN1KMT2AGAALMNAPGR | |
| SCHEMBL10328532 | 0.74 | NR1H2 (0.45) | SLC40A1CKS1BSKP2ACLY | |
| SCHEMBL10328524 | 0.72 | SLC16A3 (0.40) | MEN1KMT2AGAAPI4KAPIK3CG | |
| SCHEMBL10319006 | 0.72 | AXL (0.58) | AXLLMNANR3C1PGRAR | |
| SCHEMBL13667269 | 0.70 | RORC (0.52) | NPSR1KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262772-B1 | QUINOLINE DERIVATIVES AS AXL KINASE INHIBITORS | MAX PLANCK GESELLSCHAFT (DE) | 2012-07-18 | — | — | EP | disclosed |