Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 2/20 | 0.50 |
| ▸ | KLK14 | Q9P0G3 | 2/20 | 0.50 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.50 |
| ▸ | CTSG | P08311 | 1/20 | 0.50 |
| ▸ | CTRC | Q99895 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | TNF | P01375 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9704225 | 0.81 | TRPA1 (0.51) | MEN1KMT2AACHETNFMAOA | |
| SCHEMBL10334046 | 0.78 | MEN1 (0.44) | MEN1KMT2AACHECYP3A4ALDH1A1 | |
| SCHEMBL10333713 | 0.76 | MEN1 (0.46) | MEN1KMT2AACHETNFMAOA | |
| Bromide SCHEMBL8002743 | 0.76 | MEN1 (0.60) | MEN1KMT2AACHECYP3A4PDE10A | |
| SCHEMBL28068055 | 0.72 | MAOA (0.47) | MEN1KMT2AACHETNFMAOA | |
| SCHEMBL2460475 | 0.71 | MEN1 (0.66) | MEN1KMT2AACHETNFCYP3A4 | |
| SCHEMBL9704512 | 0.70 | TRPA1 (0.52) | MEN1KMT2AACHETNFCYP3A4 | |
| Hydrochloric Acid SCHEMBL1022954 | 0.70 | MEN1 (0.64) | MEN1KMT2AACHETNFCYP3A4 | |
| SCHEMBL954159 | 0.69 | ALDH1A1 (0.54) | MEN1KMT2AMAOACYP3A4PDE10A | |
| SCHEMBL30789068 | 0.69 | MEN1 (0.59) | MEN1KMT2AACHETNFCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4900751-A | 2-Pyridinyl-phenyl-sulphinyl-and-phenyl-thio-benzimidazoles having antiflammatory or gastic acid secretion inhibition activity | FISONS PLC (GB) | 1990-02-13 | — | — | US | disclosed |
| EP-0283504-A1 | COMPOUNDS | FISONS plc (GB) | 1988-09-28 | — | — | EP | disclosed |
| WO-1988002367-A1 | COMPOUNDS | FISONS PLC (GB) | 1988-04-07 | — | — | WO | disclosed |
| EP-0262845-A1 | Heterocyclic substituted azole derivatives | FISONS plc (GB) | 1988-04-06 | — | — | EP | disclosed |