Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10340613 | 0.93 | MAOA (0.48) | MAOAMTNR1AMTNR1BHTR1AFYN | |
| SCHEMBL8891546 | 0.82 | HTR1A (0.47) | MTNR1AMTNR1BHTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL7515525 | 0.78 | HTR1A (0.46) | MTNR1AMTNR1BHTR1ADRD2ALDH1A1 | |
| Fumaric Acid SCHEMBL7514859 | 0.76 | HTR1A (0.42) | MTNR1AMTNR1BHTR1AKDM4EALDH1A1 | |
| Succinic Acid SCHEMBL7517288 | 0.76 | HTR1A (0.45) | MTNR1AMTNR1BHTR1ADRD2ALDH1A1 | |
| Fumaric Acid SCHEMBL7515760 | 0.76 | HTR1A (0.42) | MTNR1AMTNR1BHTR1AKDM4EALDH1A1 | |
| Maleic Acid SCHEMBL7514854 | 0.76 | HTR1A (0.42) | MTNR1AMTNR1BHTR1AKDM4EALDH1A1 | |
| SCHEMBL23261875 | 0.75 | MAP3K14 (0.39) | MAOAMTNR1AMTNR1BHTR1ADRD2 | |
| SCHEMBL23261947 | 0.75 | DRD2 (0.38) | MAOAMTNR1AMTNR1BHTR1AHTR2A | |
| Propionic Acid SCHEMBL7514987 | 0.75 | HTR1A (0.49) | MTNR1AMTNR1BHTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0162695-B1 | 6-OXYGENATED-1,3,,4,5-TETRAHYDROBENZ(CD)INDOL-4-AMINES | SMITHKLINE BEECHAM CORPORATION (US) | 1990-01-17 | — | — | EP | disclosed |
| EP-0162695-A1 | 6-Oxygenated-1,3,,4,5-Tetrahydrobenz(cd)indol-4-amines | SMITHKLINE BEECHAM CORPORATION (US) | 1985-11-27 | — | — | EP | disclosed |