Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Acifluorfen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.82 |
| ▸ | MEN1 | O00255 | 2/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.82 |
| ▸ | TTR | P02766 | 1/20 | 0.82 |
| ▸ | PPOX | P50336 | 1/20 | 0.82 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CCR6 | P51684 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | PYGL | P06737 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acifluorfen SCHEMBL39453 | 0.98 | TDP1 (0.82) | TDP1MEN1KMT2ATTRPPOX | |
| Acifluorfen SCHEMBL29352750 | 0.98 | TDP1 (0.82) | TDP1MEN1KMT2ATTRPPOX | |
| Acifluorfen SCHEMBL29471425 | 0.98 | TDP1 (0.82) | TDP1MEN1KMT2ATTRPPOX | |
| Acifluorfen SCHEMBL30370086 | 0.98 | TDP1 (0.82) | TDP1MEN1KMT2ATTRPPOX | |
| Acifluorfen SCHEMBL10495341 | 0.95 | MEN1 (0.77) | TDP1MEN1KMT2ATTRPPOX | |
| Acifluorfen SCHEMBL8936622 | 0.94 | TDP1 (0.90) | TDP1MEN1KMT2ATTRPPOX | |
| Acifluorfen SCHEMBL10495355 | 0.94 | MEN1 (0.76) | TDP1MEN1KMT2ATTRPPOX | |
| SCHEMBL10379343 | 0.91 | TDP1 (0.85) | TDP1MEN1KMT2ATTRPPOX | |
| Potassium Ion SCHEMBL11126889 | 0.90 | MEN1 (0.80) | TDP1MEN1KMT2ATTRPPOX | |
| Acifluorfen SCHEMBL8028079 | 0.90 | TDP1 (1.00) | TDP1MEN1KMT2ATTRPPOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0218314-B1 | THE PREPARATION OF SUBSTITUTED 3'-BROMODIPHENYLETHERS | ROHM AND HAAS COMPANY (US) | 1990-06-27 | — | — | EP | disclosed |
| EP-0218314-A1 | The preparation of substituted 3'-Bromodiphenylethers | ROHM AND HAAS COMPANY (US) | 1987-04-15 | — | — | EP | disclosed |
| US-4588487-A | Process for the preparation of 3'-halodiphenylethers | ROHM AND HAAS COMPANY (US) | 1986-05-13 | — | — | US | disclosed |