Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acifluorfen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.90 |
| ▸ | MEN1 | O00255 | 1/20 | 0.90 |
| ▸ | TTR | P02766 | 1/20 | 0.90 |
| ▸ | PPOX | P50336 | 1/20 | 0.90 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.90 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.48 |
| ▸ | PYGL | P06737 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 6/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acifluorfen SCHEMBL39453 | 0.96 | TDP1 (0.82) | TDP1MEN1TTRPPOXKMT2A | |
| Acifluorfen SCHEMBL30370086 | 0.96 | TDP1 (0.82) | TDP1MEN1TTRPPOXKMT2A | |
| Acifluorfen SCHEMBL29352750 | 0.96 | TDP1 (0.82) | TDP1MEN1TTRPPOXKMT2A | |
| Acifluorfen SCHEMBL3690938 | 0.96 | TDP1 (0.98) | TDP1MEN1TTRPPOXKMT2A | |
| Acifluorfen SCHEMBL29471425 | 0.96 | TDP1 (0.82) | TDP1MEN1TTRPPOXKMT2A | |
| Acifluorfen SCHEMBL3228873 | 0.95 | TDP1 (1.00) | TDP1MEN1TTRPPOXKMT2A | |
| Acifluorfen SCHEMBL29448829 | 0.95 | TDP1 (1.00) | TDP1MEN1TTRPPOXKMT2A | |
| Acifluorfen SCHEMBL8028079 | 0.95 | TDP1 (1.00) | TDP1MEN1TTRPPOXKMT2A | |
| Acifluorfen SCHEMBL38929 | 0.95 | TDP1 (1.00) | TDP1MEN1TTRPPOXKMT2A | |
| Acifluorfen SCHEMBL29445767 | 0.95 | TDP1 (1.00) | TDP1MEN1TTRPPOXKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5562914-A | FOR CONTROLLED RELEASE OF ACTIVE MATERIAL THROUGH POLYURETHANE MATRIX | ZENECA INC. (US) | 1996-10-08 | — | — | US | disclosed |
| US-5563112-A | Herbicidal diphenyl ether and nitrogen solution compositions and method | ZENECA LIMITED (GB) | 1996-10-08 | — | — | US | disclosed |
| US-5173105-A | Herbicides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-12-22 | — | — | US | disclosed |
| US-5152826-A | Herbicides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-10-06 | — | — | US | disclosed |
| US-5076832-A | Certain 3-(substituted phenyl)-5-(substituted phenyl)-1-ethylimidazolidine-4-ones as herbicides | ICI AMERICAS INC. (US) | 1991-12-31 | — | — | US | disclosed |
| US-4957538-A | HERBICIDES | ICI AMERICAS INC. (US) | 1990-09-18 | — | — | US | disclosed |
| US-4869748-A | HERBICIDES | ICI AMERICAS INC. (US) | 1989-09-26 | — | — | US | disclosed |