Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHBG | P04278 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HSPA5 | P11021 | 2/20 | 0.38 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | SELL | P14151 | 1/20 | 0.37 |
| ▸ | SELP | P16109 | 1/20 | 0.37 |
| ▸ | SELE | P16581 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL69852 | 0.84 | HSPA5 (0.53) | NPC1RAB9AHSPA5AMY1ACYP2C9 | |
| SCHEMBL187792 | 0.84 | SHBG (0.52) | SHBGHSPA5AMY1ACYP2C9CYP2C19 | |
| SCHEMBL14430758 | 0.81 | NPC1 (0.38) | NPC1RAB9AHSPA5AMY1ACYP2C9 | |
| SCHEMBL16077899 | 0.81 | NPC1 (0.38) | NPC1RAB9AHSPA5AMY1ACYP2C9 | |
| SCHEMBL14534585 | 0.81 | THRB (0.38) | NPC1RAB9AHSPA5AMY1ACYP2C9 | |
| SCHEMBL27679370 | 0.79 | ALOX5 (0.40) | NPC1RAB9AHSPA5AMY1ACYP2C9 | |
| SCHEMBL64932 | 0.78 | ALDH1A1 (0.58) | NPC1RAB9ACYP2C9CYP1A2CYP2C19 | |
| SCHEMBL1907836 | 0.77 | HSD17B10 (0.59) | CYP2C9CYP1A2CYP2C19SMN1; SMN2HIF1A | |
| SCHEMBL29577605 | 0.77 | HSD17B10 (0.59) | CYP2C9CYP1A2CYP2C19SMN1; SMN2HIF1A | |
| SCHEMBL29776750 | 0.77 | HSD17B10 (0.46) | SHBGNPC1HSPA5CYP2C9CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221568-A1 | Synthesis of Inhibitors of FtsZ | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-09-03 | — | — | US | disclosed |
| EP-1957474-A1 | SYNTHESIS OF INHIBITORS OF FTSZ | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007056188-A1 | SYNTHESIS OF INHIBITORS OF FTSZ | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221568-A1 | Synthesis of Inhibitors of FtsZ | CDC42, CCNB1, CDC20 | SHBG 2707/4885NPC1 1207/4885RAB9A 898/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.