Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 12/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 12/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10367806 | 0.89 | ALDH1A1 (0.38) | GABRA1GABRG2GABRB3GABRA3KMT2A | |
| SCHEMBL10368214 | 0.89 | MAPT (0.39) | MTNR1AMTNR1BGABRA1GABRG2GABRB3 | |
| SCHEMBL10369721 | 0.84 | KCNK3 (0.35) | MTNR1AMTNR1BGABRA1GABRG2GABRB3 | |
| SCHEMBL10367826 | 0.84 | AVPR1A (0.37) | GABRA1GABRG2GABRB3GABRA3KMT2A | |
| SCHEMBL9338243 | 0.82 | GABRG2 (0.53) | MTNR1AMTNR1BGABRA1GABRG2GABRB3 | |
| SCHEMBL10367418 | 0.79 | GABRA1 (0.40) | MTNR1AMTNR1BGABRA1GABRG2GABRB3 | |
| SCHEMBL9334779 | 0.77 | TSHR (0.40) | MTNR1AMTNR1BGABRA1GABRG2GABRB3 | |
| SCHEMBL7284938 | 0.77 | MAPT (0.40) | KMT2AKDM4EMAPTNPSR1ALDH1A1 | |
| SCHEMBL9682914 | 0.76 | ALDH1A1 (0.40) | MTNR1AMTNR1BGABRA1GABRG2GABRB3 | |
| SCHEMBL9338489 | 0.76 | MAPK1 (0.46) | MTNR1AMTNR1BGABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0183994-B1 | TRICYCLIC PYRIDONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1990-03-21 | — | — | EP | disclosed |
| EP-0183994-A1 | Tricyclic pyridone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1986-06-11 | — | — | EP | disclosed |