Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 2/20 | 0.59 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.53 |
| ▸ | ICMT | O60725 | 7/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9585680 | 0.90 | PLA2G2A (0.67) | PLA2G2AMTNR1AMTNR1BICMTHTR6 | |
| SCHEMBL9585417 | 0.90 | PLA2G2A (0.67) | PLA2G2AMTNR1AMTNR1BICMTHTR6 | |
| SCHEMBL9733384 | 0.88 | PLA2G2A (0.55) | PLA2G2AMTNR1AMTNR1BICMTHTR6 | |
| SCHEMBL10380474 | 0.88 | ADAM17 (0.46) | ICMTHTR6LMNAALDH1A1ADAM17 | |
| SCHEMBL9583713 | 0.85 | PLA2G2A (0.54) | PLA2G2AMTNR1AMTNR1BICMTHTR6 | |
| SCHEMBL10443452 | 0.84 | PLA2G2A (0.67) | PLA2G2AMTNR1AMTNR1BICMTHTR6 | |
| SCHEMBL9733190 | 0.81 | PLA2G2A (0.60) | PLA2G2AMTNR1AMTNR1BICMTHTR6 | |
| Hydrochloric Acid SCHEMBL9733235 | 0.81 | PLA2G2A (0.59) | PLA2G2AMTNR1AMTNR1BICMTHTR6 | |
| SCHEMBL9583982 | 0.80 | PLA2G2A (0.48) | PLA2G2AMTNR1AMTNR1BICMTLMNA | |
| SCHEMBL9584346 | 0.78 | ICMT (0.47) | PLA2G2AMTNR1AMTNR1BICMTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375133-A1 | Alpha-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents | THE UPJOHN COMPANY (US) | 1990-06-27 | — | — | EP | claimed |
| WO-1990005721-A1 | ALPHA-AMINO-INDOLE-3-ACETIC ACIDS USEFUL AS ANTI-DIABETIC, ANTI-OBESITY AND ANTI-ATHEROSCLEROTIC AGENTS | THE UPJOHN COMPANY (US) | 1990-05-31 | — | — | WO | claimed |