Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.54 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ambasilide SCHEMBL246531 | 0.88 | HSD11B1 (0.53) | MAPK1TSHRMEN1LMNAKMT2A | |
| Ambasilide SCHEMBL427931 | 0.88 | HSD11B1 (0.53) | MAPK1TSHRMEN1LMNAKMT2A | |
| SCHEMBL10409233 | 0.87 | TSHR (0.54) | MAPK1TSHRMEN1LMNAKMT2A | |
| SCHEMBL10409271 | 0.81 | ALDH1A1 (0.60) | MAPK1TSHRMEN1LMNAKMT2A | |
| SCHEMBL10409320 | 0.80 | HSD11B1 (0.50) | MAPK1TSHRMEN1LMNAKMT2A | |
| SCHEMBL9521948 | 0.80 | ALDH1A1 (0.50) | MAPK1TSHRMEN1LMNAKMT2A | |
| SCHEMBL9521359 | 0.80 | KMT2A (0.58) | MAPK1TSHRMEN1LMNAKMT2A | |
| SCHEMBL9521802 | 0.80 | SIGMAR1 (0.50) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 | |
| SCHEMBL6318888 | 0.79 | S1PR5 (0.53) | MAPK1TSHRMEN1LMNAKMT2A | |
| SCHEMBL9523517 | 0.77 | ALDH1A1 (0.51) | MAPK1TSHRMEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4959373-A | Bispidine derivatives as class III antiarrhythmic agents | BASF AKTIENGESELLSCHAFT (DE) | 1990-09-25 | — | — | US | disclosed |
| EP-0308843-A2 | Bispidin derivatives as class III antiarrhythmics | BASF Aktiengesellschaft (DE) | 1989-03-29 | — | — | EP | disclosed |