Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR3 | P46089 | 5/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7928085 | 0.83 | ALDH1A1 (0.39) | GPR3AKR1C2AKR1C1NOTUMFFAR4 | |
| SCHEMBL11274922 | 0.81 | GPR3 (0.36) | GPR3AKR1C2AKR1C1NOTUMFFAR4 | |
| SCHEMBL22573124 | 0.80 | MAPK1 (0.34) | AKR1C2AKR1C1FFAR4DRD3MAPK1 | |
| SCHEMBL25372577 | 0.79 | GPR3 (0.35) | GPR3AKR1C2AKR1C1NOTUMFFAR4 | |
| SCHEMBL3203026 | 0.79 | AKR1C2 (0.49) | GPR3AKR1C2AKR1C1NOTUMFFAR4 | |
| SCHEMBL9224313 | 0.79 | GPR3 (0.35) | GPR3AKR1C2AKR1C1NOTUMFFAR4 | |
| SCHEMBL12536048 | 0.79 | GPR3 (0.37) | GPR3AKR1C2AKR1C1NOTUMFFAR4 | |
| SCHEMBL342267 | 0.79 | ALDH1A1 (0.44) | GPR3AKR1C2AKR1C1NOTUMFFAR4 | |
| SCHEMBL508083 | 0.79 | GPR3 (0.44) | GPR3AKR1C2AKR1C1NOTUMFFAR4 | |
| SCHEMBL34474782 | 0.79 | GPR3 (0.44) | GPR3AKR1C2AKR1C1NOTUMFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8835423-B2 | Azepine inhibitors of janus kinases | INCYTE CORPORATION (US) | 2014-09-16 | — | — | US | disclosed |
| US-20140031344-A1 | AZEPINE INHIBITORS OF JANUS KINASES | INCYTE CORPORATION (US) | 2014-01-30 | — | — | US | disclosed |
| US-8563541-B2 | Azepine inhibitors of Janus kinases | INCYTE CORPORATION (US) | 2013-10-22 | — | — | US | disclosed |
| US-20120329782-A1 | AZEPINE INHIBITORS OF JANUS KINASES | INCYTE CORPORATION (US) | 2012-12-27 | — | — | US | disclosed |
| EP-2270014-A1 | Azepine inhibitors of janus kinases | Incyte Corporation (US) | 2011-01-05 | — | — | EP | disclosed |
| US-20090197869-A1 | AZEPINE INHIBITORS OF JANUS KINASES | INCYTE CORPORATION, A DELAWARE CORPORATION | 2009-08-06 | — | — | US | disclosed |
| EP-1926735-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | Incyte Corporation (US) | 2008-06-04 | — | — | EP | disclosed |
| US-20070149506-A1 | Azepine inhibitors of Janus kinases | INCYTE CORPORATION | 2007-06-28 | — | — | US | disclosed |
| WO-2007038215-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION (US) | 2007-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120329782-A1 | AZEPINE INHIBITORS OF JANUS KINASES | JAK1, JAK3, JAK2 | GPR3 3715/4885AKR1C2 3734/4885AKR1C1 3656/4885 |
| US-20090197869-A1 | AZEPINE INHIBITORS OF JANUS KINASES | JAK1, JAK3, JAK2 | GPR3 3715/4885AKR1C2 3734/4885AKR1C1 3656/4885 |
| US-20070149506-A1 | Azepine inhibitors of Janus kinases | JAK1, JAK3, JAK2 | GPR3 3715/4885AKR1C2 3734/4885AKR1C1 3656/4885 |
| US-20140031344-A1 | AZEPINE INHIBITORS OF JANUS KINASES | JAK1, JAK3, JAK2 | GPR3 3715/4885AKR1C2 3734/4885AKR1C1 3656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.