SCHEMBL7928085

SCHEMBL7928085

FC(F)(F)Oc1cc(Cl)c(Cl)c(Cl)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.39
GPR3 P46089 3/20 0.38
AKR1C2 P52895 1/20 0.37
AKR1C1 Q04828 1/20 0.37
CYP3A4 P08684 2/20 0.36
HPGD P15428 1/20 0.36
CRHBP P24387 1/20 0.36
CRHR2 Q13324 1/20 0.36
HSD17B10 Q99714 1/20 0.36
NOTUM Q6P988 1/20 0.36
GRIN2B Q13224 1/20 0.33
MRGPRX4 Q96LA9 1/20 0.33
MAPT P10636 2/20 0.33
TRPV1 Q8NER1 1/20 0.33
FFAR1 O14842 1/20 0.33
CYP2C9 P11712 1/20 0.33
SCN5A Q14524 1/20 0.33
FFAR4 Q5NUL3 1/20 0.33
MAPK1 P28482 1/20 0.33
RECQL P46063 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19643066 0.85 ALDH1A1 (0.34) ALDH1A1GPR3AKR1C2AKR1C1NOTUM
SCHEMBL11274922 0.83 GPR3 (0.36) GPR3AKR1C2AKR1C1NOTUMGRIN2B
SCHEMBL1040929 0.83 GPR3 (0.41) GPR3AKR1C2AKR1C1NOTUMGRIN2B
SCHEMBL25372577 0.81 GPR3 (0.35) GPR3AKR1C2AKR1C1NOTUMGRIN2B
SCHEMBL9224313 0.81 GPR3 (0.35) GPR3AKR1C2AKR1C1NOTUMGRIN2B
SCHEMBL8464365 0.81 ALDH1A1 (0.36) ALDH1A1CYP3A4HPGDCRHBPCRHR2
SCHEMBL12536048 0.81 GPR3 (0.37) ALDH1A1GPR3AKR1C2AKR1C1CYP3A4
SCHEMBL3203026 0.81 AKR1C2 (0.49) ALDH1A1GPR3AKR1C2AKR1C1CYP3A4
SCHEMBL342267 0.81 ALDH1A1 (0.44) ALDH1A1GPR3AKR1C2AKR1C1CYP3A4
SCHEMBL23084107 0.80 ALDH1A1 (0.35) ALDH1A1GPR3AKR1C2AKR1C1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1140735-A1 PREPARATION OF NUCLEAR CHLORINATED AROMATIC COMPOUNDS OCCIDENTAL CHEMICAL CORPORATION (US) 2001-10-10 EP disclosed
WO-2000040524-A1 PREPARATION OF NUCLEAR CHLORINATED AROMATIC COMPOUNDS OCCIDENTAL CHEMICAL CORPORATION (US) 2000-07-13 WO disclosed
US-5981789-A CHLORODENITRATING AROMATIC COMPOUNDS USING LESS CHLORINATING AGENT AND LOWER TEMPERATURES, THEN RECYCLING THE PRODUCT MIXTURE TO INCREASE THE YIELD OCCIDENTAL CHEMICAL CORPORATION (US) 1999-11-09 US disclosed
US-4704483-A FLUORINATION WITH POTASSIUM FLUORIDE OCCIDENTAL CHEMICAL CORPORATION (US) 1987-11-03 US disclosed
US-4582948-A VAPOR PHASE CHLORO-DENITRATION REACTION OCCIDENTAL CHEMICAL CORPORATION (US) 1986-04-15 US disclosed
EP-0159388-A2 Preparation of nuclear chlorinated compounds OCCIDENTAL CHEMICAL CORPORATION (US) 1985-10-30 EP disclosed