Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10412514 | 0.94 | SLC6A2 (0.47) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL10413253 | 0.88 | SIGMAR1 (0.47) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL10413002 | 0.87 | HTR6 (0.45) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL10413763 | 0.83 | HTR1A (0.49) | HTR6KCNH2ADRA1DADRA1AADRA1B | |
| SCHEMBL10412510 | 0.83 | DRD2 (0.45) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL10413760 | 0.81 | SLC18A3 (0.48) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL10414220 | 0.80 | DRD2 (0.43) | SIGMAR1SLC6A2HTR2AHTR6KCNH2 | |
| SCHEMBL10413234 | 0.80 | HTR6 (0.49) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL10412473 | 0.76 | KCNH2 (0.46) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL10413252 | 0.76 | KCNH2 (0.52) | HTR6KCNH2ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4916143-A | Hydroxyindole esters | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-04-10 | — | — | US | disclosed |