Tyrosine

SCHEMBL10423657

CC(C)C[C@H](N)C(=O)O.CC(C)[C@H](N)C(=O)O.CC[C@H](C)[C@H](N)C(=O)O.CC[C@H](C)[C@H](N)C(=O)O.CSCC[C@H](N)C(=O)O.C[C@@H](O)[C@H](N)C(=O)O.C[C@@H](O)[C@H](N)C(=O)O.C[C@H](N)C(=O)O.C[C@H](N)C(=O)O.NC(=O)CC[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)O.NCC(=O)O.NCC(=O)O.NCC(=O)O.NCCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.N[C@@H](CCC(=O)O)C(=O)O.N[C@@H](CO)C(=O)O.N[C@@H](CO)C(=O)O.N[C@@H](CO)C(=O)O.N[C@@H](CO)C(=O)O.N[C@@H](CS)C(=O)O.N[C@@H](CS)C(=O)O.N[C@@H](CS)C(=O)O.N[C@@H](CS)C(=O)O.N[C@@H](CS)C(=O)O.N[C@@H](CS)C(=O)O.N[C@@H](Cc1ccc(O)cc1)C(=O)O.N[C@@H](Cc1ccc(O)cc1)C(=O)O.O=C(O)[C@@H]1CCCN1.O=C(O)[C@@H]1CCCN1

nearest known ligand 0.35

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

PPARD PTGS1 PTGS2 dacA dacB dacC ftsI mrcA mrcB mrdA

The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	CALCR	P30988	4/20	0.35

▸	CRHR1	P34998	1/20	0.35

▸	CRHR2	Q13324	1/20	0.35

▸	NPY2R	P49146	7/20	0.33

▸	NPY4R	P50391	7/20	0.33

▸	NPY5R	Q15761	7/20	0.33

▸	NPY1R	P25929	5/20	0.33

▸	KDM1A	O60341	2/20	0.33

▸	MAOB	P27338	1/20	0.33

▸	KDM5A	P29375	1/20	0.33

▸	KDM1B	Q8NB78	1/20	0.33

▸	VIPR2	P41587	2/20	0.33

▸	VIPR1	P32241	2/20	0.32

▸	BACE1	P56817	1/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Tyrosine SCHEMBL10424735	0.92	KDM1A (0.35)	CALCRCRHR1CRHR2KDM1AMAOB
Tyrosine SCHEMBL9538046	0.90	CRHR1 (0.40)	CALCRCRHR1CRHR2NPY2RNPY1R
Tryptophan SCHEMBL6479239	0.88	GLP1R (0.41)	CALCRCRHR1CRHR2
Tyrosine SCHEMBL27498286	0.87	CALCR (0.40)	CALCRCRHR1CRHR2VIPR2VIPR1
Tryptophan SCHEMBL6437399	0.87	GLP1R (0.41)	CALCR
Tyrosine SCHEMBL27366389	0.87	GLP1R (0.41)	CALCRCRHR1CRHR2VIPR2VIPR1
Phenylalanine SCHEMBL28835549	0.87	CALCR (0.40)	CALCRCRHR1CRHR2NPY2RNPY1R
Tyrosine SCHEMBL28760425	0.86	VIPR2 (0.43)	NPY2RNPY4RNPY5RNPY1RKDM1A
Tyrosine SCHEMBL6253686	0.86	REN (0.38)	NPY1RKDM1AMAOBKDM5AKDM1B
Tryptophan SCHEMBL27448344	0.85	GLP1R (0.44)	—

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-4929718-A	Synthetic noxiustoxin related peptides	UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO (MX)	1990-05-29	—	—	US	disclosed