Tyrosine

SCHEMBL10424735

CC(C)C[C@H](N)C(=O)O.CSCC[C@H](N)C(=O)O.C[C@H](N)C(=O)O.C[C@H](N)C(=O)O.NC(=O)CC[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)O.NCC(=O)O.NCC(=O)O.NCC(=O)O.NCCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.N[C@@H](CCC(=O)O)C(=O)O.N[C@@H](CO)C(=O)O.N[C@@H](CO)C(=O)O.N[C@@H](CO)C(=O)O.N[C@@H](CS)C(=O)O.N[C@@H](CS)C(=O)O.N[C@@H](CS)C(=O)O.N[C@@H](CS)C(=O)O.N[C@@H](CS)C(=O)O.N[C@@H](Cc1ccc(O)cc1)C(=O)O.N[C@@H](Cc1ccc(O)cc1)C(=O)O.O=C(O)[C@@H]1CCCN1

nearest known ligand 0.35

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

PPARD PTGS1 PTGS2 dacA dacB dacC ftsI mrcA mrcB mrdA

The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 13)

	gene	UniProt	supporting neighbours	confidence
▸	KDM1A	O60341	3/20	0.35

▸	MAOB	P27338	1/20	0.35

▸	KDM5A	P29375	1/20	0.35

▸	KDM1B	Q8NB78	1/20	0.35

▸	CALCR	P30988	3/20	0.32

▸	OPRM1	P35372	1/20	0.32

▸	CRHR1	P34998	1/20	0.32

▸	CRHR2	Q13324	1/20	0.32

▸	THRB	P10828	1/20	0.31

▸	KISS1R	Q969F8	2/20	0.31

▸	NTSR2	O95665	2/20	0.30

▸	NTSR1	P30989	1/20	0.30

▸	SORT1	Q99523	1/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Tyrosine SCHEMBL10423657	0.92	CALCR (0.35)	KDM1AMAOBKDM5AKDM1BCALCR
Tyrosine SCHEMBL6246872	0.87	OPRM1 (0.37)	KDM1AMAOBKDM5AKDM1BOPRM1
Tyrosine SCHEMBL10424737	0.84	SLC7A5 (0.39)	OPRM1THRB
Tyrosine SCHEMBL28889532	0.82	SLC7A5 (0.38)	KDM1AMAOBKDM5AKDM1BKISS1R
Tyrosine SCHEMBL5151728	0.82	REN (0.36)	KISS1RNTSR2NTSR1SORT1
Glutamine SCHEMBL28366405	0.82	GSR (0.34)	THRB
Tyrosine SCHEMBL28209384	0.82	SLC7A5 (0.41)	OPRM1THRB
Tyrosine SCHEMBL27454138	0.82	REN (0.35)	NTSR2NTSR1
Arginine SCHEMBL1377206	0.81	FNTA (0.35)	KDM1AMAOBKDM5AKDM1B
Dl-Phenylalanine SCHEMBL29067183	0.81	GHSR (0.39)	THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-4929718-A	Synthetic noxiustoxin related peptides	UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO (MX)	1990-05-29	—	—	US	disclosed