Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | F12 | P00748 | 1/20 | 0.37 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10612486 | 0.82 | MAPT (0.50) | ALDH1A1MAPTERCC5FEN1SMN1; SMN2 | |
| SCHEMBL4683697 | 0.81 | ALDH1A1 (0.49) | ALDH1A1MAPTERCC5FEN1SMN1; SMN2 | |
| SCHEMBL4685242 | 0.79 | ALDH1A1 (0.45) | ALDH1A1TDP1ERCC5FEN1SMN1; SMN2 | |
| SCHEMBL9726963 | 0.76 | TCF4 (0.46) | ALDH1A1TDP1MAPTERCC5FEN1 | |
| SCHEMBL3277627 | 0.73 | MAPT (0.59) | ALDH1A1MAPTSMN1; SMN2CES2CES1 | |
| SCHEMBL10385011 | 0.73 | NQO2 (0.43) | ALDH1A1TDP1MAPTERCC5FEN1 | |
| SCHEMBL9726718 | 0.72 | HMGCR (0.43) | ALDH1A1MAPTERCC5FEN1SMN1; SMN2 | |
| SCHEMBL9726725 | 0.72 | HMGCR (0.43) | ALDH1A1MAPTERCC5FEN1SMN1; SMN2 | |
| SCHEMBL9727011 | 0.71 | ALDH1A1 (0.51) | ALDH1A1TDP1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL10612472 | 0.70 | NQO2 (0.49) | ALDH1A1MAPTSMN1; SMN2RAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4898949-A | Intermediates for the preparation of antihypercholesterolemic tetrazole compounds | BRISTOL-MYERS COMPANY (US) | 1990-02-06 | — | — | US | claimed |
| WO-1988006584-A1 | ANTIHYPERCHOLESTEROLEMIC TETRAZOLE COMPOUNDS | BRISTOL-MYERS COMPANY (US) | 1988-09-07 | — | — | WO | disclosed |