Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 15/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10426115 | 0.84 | KMT2A (0.43) | ABCB1KCNH2KMT2ANR3C2 | |
| Bromide SCHEMBL10426793 | 0.83 | KMT2A (0.43) | ABCB1KCNH2KMT2ANR3C2 | |
| SCHEMBL10426114 | 0.82 | ALDH1A1 (0.40) | TSHRKCNH2KMT2AMEN1 | |
| SCHEMBL10425940 | 0.80 | MCHR1 (0.50) | ABCB1TSHRKCNH2KMT2A | |
| SCHEMBL10426726 | 0.80 | ESR1 (0.43) | KMT2AMEN1 | |
| Bromide SCHEMBL10426742 | 0.80 | MCHR1 (0.49) | ABCB1TSHRKCNH2KMT2A | |
| SCHEMBL11403943 | 0.68 | ALDH1A1 (0.46) | TSHRKCNH2KMT2AMEN1 | |
| SCHEMBL3500698 | 0.66 | SGMS2 (0.52) | KMT2AMEN1 | |
| SCHEMBL9215571 | 0.65 | NR3C1 (0.49) | KMT2ANR3C2MEN1 | |
| SCHEMBL3404910 | 0.64 | EPHX2 (0.45) | KCNH2ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4906634-A | Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents | SCHERING A.G. (DE) | 1990-03-06 | — | — | US | claimed |