Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10426793 | 0.99 | KMT2A (0.43) | KMT2AABCB1ALDH1A1HPGDLMNA | |
| SCHEMBL10426114 | 0.85 | ALDH1A1 (0.40) | KMT2AALDH1A1HPGDLMNAPOLB | |
| SCHEMBL10425941 | 0.84 | ABCB1 (0.43) | KMT2AABCB1NR3C2KCNH2 | |
| SCHEMBL10426726 | 0.83 | ESR1 (0.43) | KMT2AESR1 | |
| SCHEMBL10426113 | 0.79 | MCHR1 (0.56) | KMT2AABCB1ALDH1A1LMNAKDR | |
| Bromide SCHEMBL10426792 | 0.78 | MCHR1 (0.55) | KMT2AABCB1ALDH1A1LMNAKDR | |
| SCHEMBL11403943 | 0.70 | ALDH1A1 (0.46) | KMT2AALDH1A1LMNACHEK1AURKA | |
| SCHEMBL3500698 | 0.69 | SGMS2 (0.52) | KMT2AALDH1A1HPGDPOLBSMN1; SMN2 | |
| SCHEMBL8899486 | 0.68 | ADRA2A (0.43) | KMT2AABCB1ALDH1A1LMNAPOLB | |
| SCHEMBL11706791 | 0.67 | HPGD (0.70) | KMT2AALDH1A1HPGDLMNANR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4906634-A | Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents | SCHERING A.G. (DE) | 1990-03-06 | — | — | US | claimed |
| EP-0332570-A2 | Novel-N-(4-(Aminosubstituted)phenyl) methanesulfonamides and their use as cardiovascular agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1989-09-13 | — | — | EP | claimed |