Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 3/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 2/20 | 0.37 |
| ▸ | RXRB | P28702 | 2/20 | 0.37 |
| ▸ | RXRG | P48443 | 2/20 | 0.37 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10429318 | 0.84 | PDE4A (0.40) | CTSSS1PR1AAK1XDH | |
| SCHEMBL10429354 | 0.82 | CTSS (0.44) | CTSSS1PR1MRGPRX4S1PR4S1PR3 | |
| SCHEMBL10429352 | 0.80 | GSTP1 (0.45) | XDH | |
| SCHEMBL10429345 | 0.74 | TDO2 (0.51) | XDH | |
| SCHEMBL10429297 | 0.73 | NPSR1 (0.47) | — | |
| SCHEMBL10429320 | 0.71 | S1PR1 (0.47) | CTSSS1PR1MRGPRX4S1PR4S1PR3 | |
| SCHEMBL12648985 | 0.71 | CTSS (0.52) | CTSSS1PR1MRGPRX4S1PR4S1PR3 | |
| SCHEMBL22309147 | 0.69 | S1PR1 (0.46) | CTSSS1PR1MRGPRX4S1PR4S1PR3 | |
| SCHEMBL27612935 | 0.67 | CTSS (0.48) | CTSSS1PR1MRGPRX4S1PR4S1PR3 | |
| SCHEMBL10429360 | 0.66 | PDE3B (0.50) | XDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0274654-A2 | 1,2,3-Triazin-4(3H)-one derivatives, process for their preparation and medicaments containing them | F. HOFFMANN-LA ROCHE AG (CH) | 1988-07-20 | — | — | EP | claimed |
| US-4920119-A | XANTHINE OXIDASE INHIBITORS; CONTROL OR PREVENTION OF GOUT OR ISCHEMIA | HOFFMANN-LA ROCHE INC. (US) | 1990-04-24 | — | — | US | disclosed |
| EP-0274654-A2 | 1,2,3-Triazin-4(3H)-one derivatives, process for their preparation and medicaments containing them | F. HOFFMANN-LA ROCHE AG (CH) | 1988-07-20 | — | — | EP | disclosed |